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題 名 | 抗藥性癲癇之治療處置=Management of Drug-resistant Epilepsy |
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作 者 | 蕭淑珍; 戴慶玲; | 書刊名 | 藥學雜誌 |
卷 期 | 34:4=137 2018.12[民107.12] |
頁 次 | 頁33-38 |
分類號 | 415.932 |
關鍵詞 | 抗藥性癲癇; 癲癇手術; Drug-resistant epilepsy; DRE; Epilepsy surgery; |
語 文 | 中文(Chinese) |
中文摘要 | 使用抗癲癇藥來處置患者的癲癇發作是相當常見的治療方式,然而有將近三分 之一的癲癇患者,其發作無法以藥物適當控制,稱之為抗藥性癲癇 (drug-resistant epilepsy, DRE)。抗藥性癲癇會增加患者早夭、受傷的風險,且會使生活品質降低。 因此,及早鑑別出這類患者,以確立可能的替代療法,或者決定是否為癲癇外科手術 的適當人選,是相當重要的一件事。對於這些患者,建議合理的併用不同作用機轉的 抗癲癇藥,以發掘更有效且較少藥品不良反應的治療組合。雖然這類患者通常會考量 以癲癇手術治療,但仍有許多患者並不適合進行手術,此時便可考慮其他替代療法, 如:迷走神經刺激術 (vagus nerve stimulation) 或以生酮飲食 (ketogenic diet) 來治療。 |
英文摘要 | Antiepileptic drugs are the most often used treatment for patients with epilepsy. However, about one-third patients suffer from uncontrolled seizures despite pharmacotherapy. The seizures that occur in these patients are referred to as drug-resistant epilepsy (DRE). Patients with DRE have increased risk of premature death, injuries, and a reduced quality of life. Early identification is crucial in order to establish potential treatment alternatives and determine if the patient is a surgical candidate. Rational polytherapy is recommended in patients with DRE, with the aim to find more effective combinations with fewer adverse effects. Although epilepsy surgery is usually considered for these patients, there are many patients who are not candidates for epilepsy surgery. In these patients, other treatment alternatives such as vagus nerve stimulation or ketogenic diet are then considered. |
本系統中英文摘要資訊取自各篇刊載內容。