查詢結果分析
相關文獻
- 懷孕婦女Lamotrigine血中濃度監測的運用
- 某地區醫院附設護理之家抗癲癇藥物的使用評估
- Lung Cancer in Pregnancy: Report of Two Cases
- 新一代抗癲癇藥物
- 慈濟醫院藥物血中濃度監測報告
- Application of Transesophageal Echocardiography in a Hydrocephalic Pregnant Woman during Ventriculoatrial Shunt Operation: Report of a Case
- 懷孕婦女的手術麻醉
- 新生兒胺基醣苷類抗生素的使用
- The Intrauterine Infection of Hepatitis B Virus
- 認識新抗癲癇藥物的使用
頁籤選單縮合
題名 | 懷孕婦女Lamotrigine血中濃度監測的運用=Therapeutic Drug Monitoring of Lamotrigine |
---|---|
作者姓名(中文) | 吳芊樺; 黃俊瑋; | 書刊名 | 藥學雜誌 |
卷期 | 34:3=136 2018.09[民107.09] |
頁次 | 頁112-117 |
分類號 | 418.21 |
關鍵詞 | 懷孕婦女; 血中濃度監測; 抗癲癇藥物; Lamotrigine; Pregnancy epilepsy; Therapeutic drug monitoring; Anti-epileptic drug; Seizure; Pregnancy management; |
語文 | 中文(Chinese) |
中文摘要 | Lamotrigine (LTG) 用於抗癲癇、情緒穩定、神經痛等。同劑量 LTG 於不同病人的 實際暴露量差異很大,但有效濃度亦似乎無法獲得一致的數值範圍,因此有專家建議 以病人未發作時的數值為參考值來做調整。由於 LTG 常被建議為癲癇婦女懷孕期間用 藥,然而 LTG 在懷孕前、懷孕期間、生產後的血中濃度變化非常大。在懷孕期間,有 許多病人的 LTG 血中濃度會大幅度的下降,因此有些國家 (如:美國、日本、德國、 南澳大利亞) 的專家建議癲癇婦女懷孕應監測 LTG 的血中濃度,以減少於懷孕期間癲 癇發作而引發危險。本篇除了介紹 LTG 血中濃度監測 (LTG TDM),亦將引述目前世 界各國相關的指引與專家觀點供台灣藥師參考。 |
英文摘要 | Lamotrigine (LTG) is an effective and well-tolerated antiepileptic drug. It is also an emotional stabilizer and an antineuralgic drug. For individual patients, there is a great variety of optimal therapeutic plasma concentration. However, it is unable to obtain a consistent range of effective plasma concentration, and some experts recommend establishing personalized reference level for LTG dose adjustment. Due to the expected low risk of teratogenicity, LTG is often the first choice for the maintenance treatment of epileptic females with child-bearing potential. However, the pharmacokinetics of LTG changed unpredictably and varied considerably of patients during pregnancy. The plasma concentration of LTG decreased significantly during pregnancy and increased immediately postpartum. Without using therapeutic concentration monitoring as a reference to adjust the dose, it may cause seizure deterioration during pregnancy and increase the risk of toxicity postpartum. International experts from the United States, Japan, Germany, South Australia, recommend monitoring LTG blood concentrations to reduce the deterioration and breakthrough seizures of epileptic women during pregnancy. In addition to the introduction of LTG therapeutic drug monitoring (LTG TDM), we quoted guidelines from different countries and experts point of view as a reference for pharmacists in Taiwan. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。