查詢結果分析
相關文獻
- 海洛因成癮治療之新選擇Probuphine
- 海洛因成癮者的家庭研究
- Pulmonary Granulomatosis Associated with Insoluble Fillers in a Heroin Addict
- 海洛因成癮之藥物治療
- Nephropathy and Heroin Addiction
- 一位海洛因成癮者行為改變歷程之照護經驗--跨理論模式之應用
- 海洛因成癮者接受替代治療出席率低改善方案
- Clinical Characteristics of Heroin Injection Drug Users in Methadone Maintenance Treatment Clinic in a General Hospital
- 美沙冬替代療法對於海洛因成癮者藥物濫用信念及生活適應之成效分析
- 藥癮的罪與罰:與海洛因成癮者進行諮商的經驗
頁籤選單縮合
題名 | 海洛因成癮治療之新選擇Probuphine=An Alternative Choice for the Treatment of Heroin Addiction--Probuphine |
---|---|
作者 | 李欣雅; 許筱晴; 王治淦; 劉建宏; | 書刊名 | 藥學雜誌 |
卷期 | 34:2=135 2018.06[民107.06] |
頁次 | 頁66-71 |
分類號 | 415.8753 |
關鍵詞 | 皮下植入劑型; Buprenorphine/naloxone舌下錠; 鴉片類物質濫用成癮; 海洛因成癮; Probuphine; Buprenorphine; |
語文 | 中文(Chinese) |
中文摘要 | Probuphine 是含有 buprenorphine 的皮下植入劑型藥品,2016年5月由美國食品藥 物管理局 (Food and Drug Administration, FDA) 正式核准上市。Probuphine 主要使用 ProNeuraTM 藥物傳遞系統為其核心技術,它可以提供持續釋放劑量、穩定的血中濃度 及維持高達六個月的療效。相較於舌下錠的藥品,此種技術的優點就是病人不需要每 天服藥,減少病人順從性不良的缺點及減少病人多服劑量或濫用藥品的可能。目前研 究顯示,Probuphine 治療組別具有較高無濫用鴉片類物質及鴉片類物質持續戒斷的比 例,但 Probuphine 於植入部位的紅、腫、痛的反應仍然是經常被抱怨的主要副作用。 本篇文章主要是提供 Probuphine 相關於藥物動力學特性、臨床治療療效及副作用簡 介,以提供未來鴉片類物質成癮維持治療之用藥新選擇。 |
英文摘要 | Probuphine are subdermal implants of buprenorphine and were approved by the US Food and Drug Administration (FDA) on May, 2016. Using the ProNeuraTM drug delivery platform, it provides patients constant dosages amounts for up to 6 months and releases the drug to maintain steady-state concentrations. Comparing to using sublingual buprenophine/ naloxone, it is convenient to using probuphine for decreasing patient nonadherence to miss oral dose and to reduce patient abuse opioid drugs. Recently studies showed that patients receiving probuphine have less opioid drugs abuse and higher maintained opioid abstinence. However, the most complained adverse reactions are implanted-related events in implant site, such as pain, pruritus, and erythema. Thus, the purpose of this study is to introduce the pharmacokinetics, the treatment efficacy and safety of probuphine to provide an alternative choice for the maintenance treatment of opioid addiction in the future. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。