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頁籤選單縮合
題名 | 免疫之於癌細胞=Immunity in Cancer Cells |
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作者 | 鄭吉元; 蔡慈貞; 張文震; | 書刊名 | 藥學雜誌 |
卷期 | 34:2=135 2018.06[民107.06] |
頁次 | 頁16-19 |
分類號 | 414.82 |
關鍵詞 | 癌症; 先天免疫; 後天免疫; Cancer; Innate immunity; Adaptive immunity; |
語文 | 中文(Chinese) |
中文摘要 | 人體免疫系統可主動辨識癌細胞並將之清除,而癌細胞則會透過免疫編輯的過程 對免疫系統產生抗性。免疫編輯有三階段,包括清除、平衡、逃脫。人體免疫系統包 括先天和後天免疫。先天免疫細胞有巨噬細胞、嗜中性白血球、樹突細胞、自然殺手 細胞,它們可在第一時間直接對付癌細胞;後天免疫細胞主要是T淋巴細胞 (T細胞) 和 B淋巴細胞 (B細胞)。樹突細胞會將癌細胞分解後形成抗原以結合主要組織相容性複合 體 (MHC) 呈現給T細胞,再加上共同刺激訊號下可活化T細胞,來執行殺死細胞內癌 細胞工作。B細胞分化為漿細胞以產生抗體,可直接對抗癌細胞。我們的先天和後天 免疫系統始終在監視及對付癌症,但是癌細胞可藉由許多方式來抑制免疫反應。如何 克服這些障礙是現今癌症免疫治療的課題。 |
英文摘要 | Human immune system can actively identify and eliminate cancer cells. However, cancer cells can carry out the immunity resistance through immunoediting. Cancer immunoediting is a process consisting of three phases: elimination, equilibrium, and escape. Our immune system is divided into two arms: the innate and adaptive immune systems. The innate immune cells include macrophages, neutrophils, dendritic cells, and natural killer cells. Among them, activated natural killer cells kill cancer cells directly. The adaptive immune cells are mainly T lymphocytes (T cells) and B lymphocytes (B cells). The dendritic cell presents the digested tumor antigens on its surface in conjunction with MHC proteins and the T cell recognizes the MHC-antigen complex, and then through the action of additional co-stimulatory signals, the T cell becomes activated to kill cancer cells intracellularly. The B cells differentiate into the plasma cells to produce antibodies that can be directly against cancer cells. Our innate and adaptive immune systems are always surveilling and fighting cancer, but cancer cells can suppress the immune response in many ways. How to overcome these obstacles is the subject of cancer immunotherapy nowadays. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。