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題 名 | The Newly Diagnosed Amnestic Disorders and Dementia: A Nationwide, Cohort Study in Taiwan=新診斷失憶症與失智症:一項全國性之世代研究 |
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作 者 | 高廉程; 簡戊鑑; 鍾其祥; 葉慧雯; 周雨青; 黃三原; 葉啟斌; 張勳安; 高譽誠; 江瑋珊; 葉奕緯; 曾念生; | 書刊名 | Taiwanese Journal of Psychiatry |
卷 期 | 32:1 2018.03[民107.03] |
頁 次 | 頁18-28+a2 |
分類號 | 415.847 |
關鍵詞 | 失憶症; 失智症; 全民健保資料庫; 世代研究; Amnestic disorders; Dementia; National Health Research Institute Database; Cohort study; |
語 文 | 英文(English) |
中文摘要 | 目的:探討新診斷失憶症與失智症之關聯性。方法:我們使用全民健保資料庫之百萬歸人檔,辨識出 5,396 位年齡 20 歲以上且無過去失憶症病史之研究組病人。其中,1,349 位為新診斷失憶症病人,依據年齡、性別、人口學變項、查爾森共病指數及指標日期等變項,以傾向分數進行配對,依1:3 之比例,取得4,062 位為對照組。以范—葛瑞二氏競爭風險存活分析比較10 年追蹤期間兩組發生失智症之風險。結果:個案組中,1,349 位病人有440 位(32.62%) 出現失智症而控制組中4,047 位病人有155 位 (3.83%) 出現失智症。競爭風險存活分析呈現研究組個案有顯著的較高風險出現失智症 (hazard ratio = 17.536, 95% confidence interval= 14.487 - 21.226, p < 0.001)。經過性別、年齡、月收入、都市化程度、居住區域及共伴疾病之校正後,其出現顯著的失智症之風險比為 17.222 (95% CI = 13.611 - 20.078),而且也有顯著的高風險性 (p < 0.001)。結論:新診斷失憶症之病人出現失智症之風險為16 倍。 |
英文摘要 | Objective: We intended to study the association between the newly diagnosed amnestic disorders and dementia. Methods: We used a subset of Taiwan’s National Health Research Institute Database, containing one million randomly sampled subjects to identify 5,396 patients aged ≥ 20 years without a history of amnestic disorders. We enrolled 1,349 patients with newly diagnosed amnestic disorders, and propensity score-matched 4,047 controls for age, gender, demographic covariates, Charlson comorbidity index, and index-date at a ratio of 1: 3. After adjusting for confounding factors, we used Fine and Gray’s competing risk survival analysis to compare the risk of developing dementia of the two groups during a 10-year follow-up. Results: Of the study subjects, 440 in 1,349 (32.62%) developed dementia compared to 155 in 4,047 (3.83%) of the controls. The study subjects were significantly to develop dementia (hazard ratio = 17.536, 95% confidence interval = 14.487 - 21.226, p < 0.001). After adjusting for confounding factors, the HR for dementia was 16.531 (95% CI =13.611 - 20.078), which also significantly different (p < 0.001). Amnestic disorders were significantly associated with the increased risk of Alzheimer, vascular, senile and pre-senile, and alcoholic types of dementia (all p < 0.001) Conclusion: The patients with newly diagnosed amnestic disorder had a 16-fold increased risk of developing dementia. |
本系統中英文摘要資訊取自各篇刊載內容。