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頁籤選單縮合
題 名 | Imatinib血中濃度監測=Therapeutic Drug Monitoring of Imatinib: Clinical Significance and Practicability |
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作 者 | 吳芊樺; 黃俊瑋; 林亮光; 黃俊達; | 書刊名 | 藥學雜誌 |
卷 期 | 33:2=131 2017.06[民106.06] |
頁 次 | 頁85-91 |
分類號 | 418.1 |
關鍵詞 | 血中濃度監測; 慢性骨髓性白血病; 胃腸道基質瘤; 酪氨酸激酶抑製劑; Imatinib; Glivec; Therapeutic drug monitoring; Chronic myeloid leukemia; Gastrointestinal stromal tumor; Tyrosine kinase inhibitors; |
語 文 | 中文(Chinese) |
中文摘要 | 許多研究發現,慢性骨髓性白血病及胃腸道基質瘤病人服用固定劑量的 imatinib 於穩定期波谷血中濃度的變異性很大。此外,陸續有研究發現慢性骨髓性白血病及 進階型胃腸道基質瘤的病人,若 imatinib 波谷血中濃度較高,則病人有較佳的療效反 應。由於 imatinib 除病人間的藥物動力學變異大,且其療程所費不貲,又考量到病人 的服藥配合度可能不如預期且需長時間服用,是否能藉由血中濃度監測使病人達最佳 治療成效,值得探討。 |
英文摘要 | Several studies demonstrated that fixed dose imatinib has great interpatient trough concentration variability in chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST). Besides, researchers have revealed that imatinib trough concentration in the steady state has a correlation with clinical efficacy in CML and advanced GIST. Those who have better response have higher imatinib trough concentration. Instead of significant interpatient pharmacokinetic variability, imatinib has extremely low adherence, high drug cost and long-term administration requirement. These reasons make imatinib a suitable candidate for therapeutic drug monitoring (TDM). It is worthwhile to discuss and investigate the clinical significance and the practicability of imatinib TDM. |
本系統中英文摘要資訊取自各篇刊載內容。