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題名 | 簡介藥物過敏反應之篩檢工具=Introduction of Objective Tests for Drug Allergy |
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作者 | 呂宛真; 李韋瑩; 王仁佑; Lu, Wan-chen; Lee, Wei-ying; Wang, Jen-yu; |
期刊 | 藥學雜誌 |
出版日期 | 20161200 |
卷期 | 32:4=129 2016.12[民105.12] |
頁次 | 頁109-114 |
分類號 | 418.11 |
語文 | chi |
關鍵詞 | 藥物過敏; 基因檢測; 皮膚測試; Drug allergy; Anaphylaxis; Skin test; |
中文摘要 | 在評估藥物不良反應案件時,有時會碰到多種藥物都有嫌疑,從時序上無法確知 是哪一個特定藥物所造成的情況。如果又是危急生命的不良反應,如過敏性休克或嚴 重皮膚不良反應,當日後需要進行醫療時,就會發生不敢用藥或無藥可用的窘境。隨 著對免疫機轉的了解及藥物基因體學的發展,目前已有許多種體外的藥物過敏檢測方 式及基因檢測,配合傳統的皮膚測試,來協助我們鑑定過敏藥物。本文將簡介目前在 臨床上可以使用的藥物過敏檢測工具,包括基因篩檢,用於第一型及第四型過敏反應 之體外測試與皮膚測試,讓藥師們在碰到類似案例時,知道還有這些方式可以協助病 人與醫療人員,去減少用藥的恐懼與困擾。 |
英文摘要 | In assessing the cases of adverse drug reactions, sometimes there were not only one culprit drug had suspected. If this adverse reaction was life-threatening, such as anaphylactic shock or severe cutaneous adverse reaction, all suspected culprit drugs would never be prescribed thereafter. The restriction of drug use may cause dilemma in medical treatment. With understanding the mechanism of drug hypersensitivity reaction and the development of pharmacogenomics, there are many kinds of in vitro diagnostic tests, with traditional skin tests, to help us identify most possible culprit drug. This article will introduce the drug allergy diagnostic tests that can be used in clinical practice, including genetic screening, skin tests and in vitro tests for type 1 and type 4 hypersensitivity reactions. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。