查詢結果分析
來源資料
相關文獻
- Role of Interleukin-6 in Transdifferentiation of Bone Marrow Stem Cells into Salivary Acinar Cells
- 淺談幹細胞研究之展望
- 幹細胞在婦產科之應用
- Pure Red Cell Aplasia after ABO Major-Mismatched Allogeneic Peripheral Blood Stem Cell Transplantation Successfully Treated with Plasma Exchange and Low-Dose Steroid: Two Case Reports
- Shockwaves Enhance the Osteogenetic Gene Expression in Marrow Stromal Cells from Hips with Osteonecrosis
- 骨髓幹細胞與再生醫學
- Clinical Pictures of 28 Case with Pathology-proven Cytomegalovirus Pneumonia
- 科技時代的菩薩行誼--當代臺灣佛教對增進社會福祉的貢獻
- 成人睪丸的「幹睪丸間質細胞」:特徵、調節與潛在應用
頁籤選單縮合
題 名 | Role of Interleukin-6 in Transdifferentiation of Bone Marrow Stem Cells into Salivary Acinar Cells=Interleukin-6在骨髓幹細胞轉分化成唾液腺細胞過程中所扮演的角色 |
---|---|
作 者 | 林佳詠; 柯美蘭; 楊志滿; 陳昭瑜; 陳易駿; 陳敏慧; | 書刊名 | 醫學與健康期刊 |
卷 期 | 6:1 2017.03[民106.03] |
頁 次 | 頁23-36 |
分類號 | 368.5 |
關鍵詞 | 骨髓幹細胞; 唾液腺細胞; 轉分化; BMP-6/IL-6迴圈; Bone marrow stem cells; Salivary acinar cells; Transdifferentiation; BMP-6/IL-6 loop; |
語 文 | 英文(English) |
英文摘要 | OBJECTIVES: In this study, we investigated how the genes, IL-6 and BMP-6, contribute to transdifferentiation of bone marrow stem cells (BMSCs) into acinar cells (ACs). METHODS: Bone marrow stem cells and salivary acinar cells were indirectly co-cultured using double-chamber systems. During co-culture, BMP-6 was added. Transdifferentiation efficiency was measured by amylase activity assay. BMP-6 expression in co-cultured BMSCs and the IL-6 concentration in cultured media were assessed using ELISA. The phosphorylation of STAT3 and the downstream factor of IL-6 signal pathway were observed by western blot. RESULTS: During indirect co-culture, the addition of BMP-6 stimulated BMSCs and increased transdifferentiation from 50% to 80%. The BMP-6 expression in co-cultured BMSCs was higher than in individually cultured BMSCs. The cultured medium of ACs had the highest IL-6 concentration, compared to co-cultured media. By adding BMP-6, IL-6 concentration further decreased. Individually cultured BMSCs showed STAT3 expression but indistinct phosphorylation. However, there was clear phosphorylation of STAT3 in co-cultured BMSCs. CONCLUSION: Many studies report IL-6 and CEBPB induce the expression of BMP-6. We found BMP-6 to be crucial to the promotion of transdifferentiation. This finding combined with the results of IL-6 concentration in cultured media suggest that a BMP-6/IL-6 loop plays 1Dentistry Department, Taichung Hospital, Ministry of Health and Welfare, Taiwan (R.O.C.) 2Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taiwan (R.O.C.) 3Dentistry Department, College of Oral Medicine, Chung Shan Medical University, Taiwan (R.O.C.) 4Ophthalmology Department, National Taiwan University Hospital Hsinchu Branch, Taiwan (R.O.C.) 5Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Taiwan (R.O.C.) 6Department of Laboratory Medicine, National Taiwan University Hospital Hsinchu Branch, Taiwan (R.O.C.) 7Department of Mechanical Engineering, National Chiao Tung University, Taiwan (R.O.C.) *Corresponding author: Min-Huey Chen, E-mail: minhueychen@ntu.edu.tw, Accepted: Nov. 21, 2016. Code: JMH-2016R-04 an important role in this process. Moreover, phosphorylated STAT3 in co-cultured BMSCs was clearly observed but not in individually cultured BMSCs. |
本系統中英文摘要資訊取自各篇刊載內容。