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| 題 名 | 帕金森氏病的治療=Treatment of Parkinson's Disease |
|---|---|
| 作 者 | 張裕英; | 書刊名 | 藥學雜誌 |
| 卷 期 | 32:2=127 2016.06[民105.06] |
| 頁 次 | 頁99-105 |
| 分類號 | 418.2251 |
| 關鍵詞 | 帕金森氏病; 左旋多巴胺; 異動症; Parkinson's disease; Levodopa; Dyskinesia; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 帕金森氏病 (Parkinson's disease,PD),是與年齡相關的神經退化性疾病,常好發在 高齡族群。造成 PD 的原因有可能是疾病、環境毒素、藥物、基因遺傳,導致黑質體分 泌多巴胺的神經元減少或消失,而引起運動失調。依照 Modified Hoehn-Yahr 分級,PD 主要分為五期。此疾病通常以國際通用評量表 Unified Parkinson's Disease Rating Scale 來 評估嚴重度。藥物治療有七大類,以左旋多巴胺為主要核心治療藥物,但因病情而需要 長期服藥,長期服藥後可能出現異動症。由於藥物不能防止腦部退化,所以儘量以能控 制病情低劑量的左旋多巴胺製劑,多巴胺促動劑,抗乙醯膽鹼藥物,隨病情藥物劑量也 會越用越高。早期的外科治療有灼燒手術、伽瑪刀放射手術,近來的腦深層電刺激可改 善 PD 的運動症狀,也逐步納入健保給付,但也無法防止腦部退化。目前研發的幹細胞 移植及基因治療等都是頗具希望的創新技術。 |
| 英文摘要 | Parkinson's disease (PD) is an age-related neurodegenerative disease, often occurring in the elderly population. The possible causes of PD include the diseases, environmental toxins, drugs, and genetic inheritance that result in the loss or decrease of dopamine neurons in substantia nigra leading to movement disorder. The development of PD can be classified into five major stages based on the modified Hoehn-Yahr scale. The severity of this disease is usually assessed using the Unified Parkinson's Disease Rating Scale (UPDRS). There are seven categories of drug therapy in PD, with levodopa being the core drug. However, as the treatment of PD requires long-term medications, movement disorders or dyskinesia may occur as a result. Since medication cannot halt brain degeneration, the disease is often controlled through use of low-dose levodopa, dopamine agonists, and anti-cholinergics, and the dosage increases over time. Early application of surgical treatments such as burn surgery, gamma knife radiosurgery, and more recently; deep brain stimulation, has been proven useful for improving the motor symptoms of PD, and thus gradually incorporated into health insurance coverage. As these procedures also do not serve to prevent brain degeneration, new technologies such as stem cell transplantation and gene therapy are under development. |
本系統中英文摘要資訊取自各篇刊載內容。