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頁籤選單縮合
題 名 | Levofloxacin用於老年泌尿道感染=Safety and Efficacy of Levofloxacin in Elderly with Urinary Tract Infections |
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作 者 | 黃美嫆; 汪忠炫; | 書刊名 | 藥學雜誌 |
卷 期 | 32:1=126 2016.03[民105.03] |
頁 次 | 頁108-114 |
分類號 | 418.281 |
關鍵詞 | 泌尿道感染; 長期照護機構; Levofloxacin; Gram(-) bacilli; Escherichia coli; |
語 文 | 中文(Chinese) |
中文摘要 | 泌尿道感染為老人最常見的感染之一,社區老人之細菌感染有25%為泌尿道感 染,長照機構老人的細菌感染則有30%為泌尿道感染。老人泌尿道感染的致病菌以大 腸桿菌 (Escherichia coli) 最常見。Levofloxacin 是屬於第三代的 fluoroquinolone 類藥 物,適應症為治療成人複雜性尿道感染 (包括:腎盂腎炎)。因此評估 levofloxacin 治 療老人泌尿道感染療效及安全,以提供醫師對抗生素的選擇。以回溯性評估方法,收 集從2011年1月至12月,診斷碼為 (ICD-9-CM 5990),使用 levofloxacin 500 mg 靜脈注 射治療泌尿道感染的65歲以上病人,以 SPSS 17將資料進行分析,P值 < 0.05具統計 上意義。128位病人經 levofloxacin 治療後125位存活,存活率97.7% (125/128)。病人 基本特徵,男性41位 (32%),女性87位 (68%)。平均年齡81.1 ± 7.3歲,47位 (36.7%) 有高血壓疾病,42位 (32.8%) 有腎功能不全。病人使用 levofloxacin 治療前 WBC 平均 11952.8 ± 4969.0 (/uL),CRP 平均9.6 ± 8.3 (mg/dL),Seg 平均80.7 ± 9.4 (%)。藥物 平均使用6.2 ± 3.4天,治療後病人的 WBC、Seg 與 CRP 有明顯改善,其 P 值分別為 (0.002;0.001;0.000)。尿液分離出前二名菌種分別為 Escherichia coli 及 Escherichia coli (ESBL)。研究發現經 levofloxacin 治療泌尿道感染後,存活率97.7% (125/128),老 年病人診斷為泌尿道感染,抗生素 levofloxacin 提供一個藥物治療選項。 |
英文摘要 | Urinary tract infections are the most common infections in the elderly. Community and long term care institutions for the elderly bacterial infections were 25% and 30% for UTI, the most common pathogenic bacteria Escherichia coli infection, second gram-negative pathogens bacteria. Levofloxacin, a member of the quinolones class of antibiotics, its has been approved for use in treatment of uncomplicated and complicated urinary tract infection. This study is a retrospectively, totally 128 patients over the age of 65 with UTI infection which were treated with levofloxacin in hospitalized older people for over three days from January 2011 to December were reviewed. SPSS 17.0 was used for statistical analysis. Results: the survival rate was 97.7% (125/128) after treatment with levofloxacin. Base- line characteristics of 128 patients. Man was 41 (32%), female 87 was (68%). Age (yr) was 81.1 ± 7.3, hypertension was 47 (36.7%) and 42 (32.8%) was renal insufficiency. Medication of days average was 6.2 ± 3.4 (days ). The white blood cell count (WBC) average was 11952.8 ± 4969.0 (/uL), C-reactive protein (CRP) average was 9.6 ± 8.3 (mg/dL) and Segmented neutrophil (Seg) average was 80.7 ± 9.4 (%). The white blood cell count (WBC), C-reactive protein (CRP), Segmented neutrophil (Seg) level were significantly different with before levofloxacin treatment compared with after levofloxacin treatment (p-value = 0.002; 0.001; 0.000). That have two most prevalent microorganisms isolated from urine samples were Escherichia coli and Escherichia coli (ESBL). In summary, our studies have shown that survival rate are 97.7%, levofloxacin is a significant drug in the treatment of hospitalized elderly patients with urinary tract infections. |
本系統中英文摘要資訊取自各篇刊載內容。