查詢結果分析
來源資料
相關文獻
- IgG4相關性疾病
- IgG4相關性疾病與肥厚性硬腦膜炎
- Tumefactive IgG4-related Disease in Otolaryngology Field
- 偉大的模仿者:IgG4相關性疾病
- IgG4-related Disease Presenting as Peri-orbital Swelling
- Küttner Tumor on FDG PET/CT Is Helpful to Differentiate IgG4-related Disease from Pancreatic Cancer: A Case Report
- High Serum IgG4 and Various Pulmonary Disease: Friend or Foe?
頁籤選單縮合
題名 | IgG4相關性疾病=IgG4-related Disease |
---|---|
作 者 | 許紘瑞; 陳相成; 朱士傑; | 書刊名 | 內科學誌 |
卷期 | 27:1 2016.02[民105.02] |
頁次 | 頁19-28 |
分類號 | 415.69 |
關鍵詞 | IgG4相關性疾病; 淋巴漿細胞浸潤; 席紋樣纖維化; B細胞清除療法; IgG4-related disease; IgG4-RD; Lymphoplasmacytic infiltration; Storiform fibrosis; B-cell depletion therapy; |
語文 | 中文(Chinese) |
中文摘要 | IgG4相關性疾病是一個全身性發炎纖維化的疾病,最近十年才獲得廣泛的重視與了解,且幾乎在身體每個器官組織都可能發現。此疾病的特徵為腫瘤樣的病灶、IgG4 陽性淋巴漿細胞浸潤 (lymphoplasmacytic infiltration)及席紋樣纖維化(storiform fibrosis),血清中IgG4濃度常有升高現象。此疾病的診斷主要經由病理組織切片及免疫化學染色來確認,其中淋巴漿細胞浸潤、席紋樣纖維化、及閉塞性靜脈炎(obliterative phlebitis)是病理診斷的典型特徵。IgG4相關性疾病的治療包括類固醇、免疫抑制劑及B細胞清除療法(B-cell depletion therapy)。本文藉由回顧最新文獻,使臨床醫師對IgG4 相關性疾病有深入的了解,並在疾病初期予以診斷及治療,避免此疾病產生器官損壞、嚴重纖維化甚至死亡。 |
英文摘要 | IgG4-related disease (IgG4-RD) is a newly recognized fibroinflammatory disease involving essentially any organ. The disease is characterized by tumefactive lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and often (but not always) elevated serum concentrations of IgG4. The diagnosis is based upon histopathological and immunohistochemical assessment. The lymphoplasmacytic infiltration, storiform fibrosis, and obliterative phlebitis are three major pathology features of IgG4-RD. Treatment options include corticosteroids, immunosuppressive drugs, and B-cell depletion therapy. Clinicians should be aware of the disease and ensure early diagnosis and therapy, which can stop organ damage, disabling tissue fibrosis, and death. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。