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題名 | 藥師介入住院病人Phenytoin監測分析=Pharmacist Intervene Inpatients Effectiveness Analysis of Monitoring Phenytoin |
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作者 | 張有邑; 李浩賢; 蔡佩玲; 莊謹如; 廖玲巧; | 書刊名 | 藥學雜誌 |
卷期 | 31:4=125 2015.12[民104.12] |
頁次 | 頁111-117 |
分類號 | 418.21 |
關鍵詞 | 藥師介入; 癲癇; 監測; Phenytoin; |
語文 | 中文(Chinese) |
中文摘要 | 目的:本研究探討藥師介入住院之癲癇病人,監測 phenytoin 治療成效。 方法:為回溯式世代研究法,研究時間為2011年1月1日至2012年7月31日,對 象為本院使用 phenytoin 之住院病人。實驗組為有藥師主動介入監測 (2012年1月至7 月);對照組為沒有藥師介入監測 (2011年1月至12月)。比較兩組間,監測血中濃度時 間正確率、以血清白蛋白校正 phenytoin 濃度比率及 phenytoin 於治療濃度範圍內的比 率。使用 Chi-square test 及 t-test 作為統計方法,以 P < 0.05視為統計學上有顯著之差 異。 結果:共收入321位病人,排除適應症非癲癇的病人39位、使用 phenytoin 小於4 天者共170位,剩餘112位病人,分別為實驗組30位,對照組82位。分析監測血中濃 度時間正確率,兩組間無顯著差異 (實驗組90%、對照組80.4%,P = 0.393);以血清 白蛋白校正 phenytoin 濃度比率,兩組間有顯著差異 (實驗組90%、對照組69.5%,P = 0.028);phenytoin 於治療濃度範圍比率,兩組間沒有顯著差異 (實驗組59.3%、對照組 40.7%,P = 0.157)。 結論:藥師介入監測機制,提升了病人使用 phenytoin 時,以血清白蛋白校正濃 度的比率,而提高濃度判讀與調整劑量的正確率。 |
英文摘要 | Objectives: Pharmacist intervene epileptic inpatients effectiveness analysis of monitoring phenytoin in this study. Methods: For retrospective cohort study of period is January 1, 2011 to July 31, 2012. Subjects included inpatients using phenytoin. The pharmacist intervention group in monitoring phenytoin during January to July 2012; The control group was no pharmacist intervention monitoring during January to December 2011. Comparison between the two groups, including the correct sampling time, adjusting phenytoin concentration by albumin and therapeutic concentration in 10-20 mcg/mL. Using the Chi-square test and t-test as a statistical method, P < 0.05 is regarded as statistically significant the difference. Results: A total of 321 patients, excluding non-epilepsy indications of 39 patients and phenytoin using less than 4 days of 170 patients. There were 30 patients in the intervention group while 82 patients in the control group. Correct sampling time was no significant difference between the two groups (intervention group 90%, control group 80.4%, P = 0.393); Adjusting phenytoin concentration by albumin was significant difference between the two groups (intervention group 90%, the control group 69.5%, P = 0.028); Therapeutic concentrations in 10-20 mcg/mL was no significant difference between the two groups (intervention group 59.3%, control group 40.7%, P = 0.157). Conclusions: The mechanism of pharmacist intervention monitoring enhanced ratios of adjusting phenytoin concentration by albumin when the epileptic inpatients use phenytoin. |
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