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題名 | 四種中藥標準品開發暨研議供應機制之研究=Four Chinese Herbal Standards Preparation and Colloquium for Chinese Herbal Standard Supply Protocol |
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作者姓名(中文) | 陳立耿; | 書刊名 | 中醫藥年報 |
卷期 | 3 2014.12[民103.12] |
頁次 | 頁(92)1-(92)67 |
分類號 | 414.3 |
關鍵詞 | 中藥; 指標成分; 土茯苓; 何首烏; 射干; 甘草; Chinese herbal medicine; Reference standard; Astilbin; Irisflorentin; Liquiritin; 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside; |
語文 | 中文(Chinese) |
中文摘要 | 本研究以土茯苓、何首烏、射干及甘草等四種中藥材為材料,分別進行 astilbin, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, irisflorentin與 liquiritin等共四種指標成分製備,量產純度大於 98 %之 astilbin, 2,3,5,4'-tetrahydroxystilbene-2O-β-D-glucoside, liquiritin及 irisflorentin分別為 2.1公克、 2.3公克、 6.6公克及 1.3公克,各成分完成結構鑑定與純度分析並制定高純度標準品分離純化之生產流程。針對 93-102年所取得之 90種中藥標準品進行純度分析,僅有 61種純度高於 95%,而其中重量大於 2克者僅有 33種。標準品供應審議會議已召開,經過討論提出標準發放之相關辦法及申請表格草案。本計畫製備中藥標準品將可落實台灣中藥典對中藥品項之 HPLC定量檢驗,提升中藥用藥之安全性,並使中草藥邁向國際化。 |
英文摘要 | The goal of this plan is to establish the standard preparation methods for reference standards of four Chinese herbal medicines, Smilacis Glabrae Rhizoma, Polygoni Multiflori Radix, Belamcandae Rhizoma, and Glycyrrhizae Radix et Rhizoma. At present, we have purificated the astilbin from Smilacis Glabrae Rhizoma, 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside from Polygoni Multiflori Radix, irisflorentin from Belamcandae Rhizoma, and liquiritin from Glycyrrhizae Radix et Rhizoma. We have preparative purified 2.1 g of astilbin, 2.3 g of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, 6.6 g of liquiritin and 1.3 g of irisflorentin with purity more than 98%. For the 90 reference standards which obtained in 2004-2013, purity analyses were performed by high-performance liquid chromatography. Sixty-one compounds have purity more than 95%, but only 33 compounds have weight more than 2 g. The colloquium for Chinese herbal standard supply protocol was convoking, the draft protocol was provided. The preparation of Chinese herbal medicine national reference standards will be a great benefit to quality control and safty of Chinese herbal medicines. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。