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題 名 | 減肥中草藥之藥效與肝腎毒性的評估=Evaluation on the Anti-obesity Efficacy as Xell as Kidney and Liver Toxicity Induced by Chinese Medicinal Plants |
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編 次 | (2-1) |
作 者 | 劉怡旻; | 書刊名 | 中醫藥年報 |
卷 期 | 3 2014.12[民103.12] |
頁 次 | 頁(13)1-(13)62 |
分類號 | 414.5 |
關鍵詞 | 肥胖; 何首烏; 柴胡; 炮製品; 肝毒性; 腎毒性; Obesity; Ho-Shou-Wu; Chai Hu; Processed products; Hepatotoxicity; Nephrotoxicity; |
語 文 | 中文(Chinese) |
中文摘要 | 研究目的:本計畫針對市面上常用於改善高血脂作用的柴胡 (Bupleuri Radix)與何首烏 (Polygoni Multiflori Radix)以及藥材炮製品,製首烏與醋柴胡,評估是否具有改善高熱量飼料引至實驗動物罹患肥胖症之效果,同時針對長期服用這些待測中藥及其炮製品後是否可能引至肝毒性、腎毒性進行評估。 研究方法:本研究利用成人建議治療劑量,分別將生柴胡和其醋製炮製品 (每日 3~15克)以及生首烏與其經黑豆汁拌蒸後所得之製首烏 (每日 10~30克)以大白鼠相對於人體之代謝係數進行換算後的劑量利用胃管每日單一次餵食的方式連續十二周投予至肥胖大鼠:本計畫投予至實驗大鼠的柴胡與醋柴胡其每日口服劑量範圍為0.3-1.5克;投予何首烏與製首烏至實驗大鼠的每日口服劑量範圍為 1-3克。實驗期間定期觀察肥胖大鼠體重以及白色脂肪組織重量的變化,配合白色脂肪細胞病理切片分析所得結果,評估待測中藥材及其炮製品減肥之藥效。藉由血液中肝功能生化指數麩丙酮酸轉胺基酶 (glutamyl pyruvic transaminase, GPT)及麩草酸轉胺基酶 (glutamyl oxaloacetic transaminase, GOT)與血漿肌酐酸 (serum creatinine)、血尿素氮(blood urea nitrogen)濃度的變化與肝臟與腎臟病理切片分析所得結果,評估待測中藥材及其炮製品對實驗動物肝臟以及腎臟傷害的可能性。 結果與討論:連續餵食十二周後可見柴胡及其醋製炮製品均有改善肥胖大鼠血脂異常的效力,同時具有抑制白色脂肪細胞體積增大以及減緩脂質過氧化與肝臟脂肪異常蓄積的作用;這項作用可能與增加肝臟氧化體增殖活化受體 (peroxisome proliferators activated receptor α, PPARα)以及脂質氧化相關酵素 acetyl-CoA oxidase (ACO)的表現有關。但是醋柴胡的這些效力均較生柴胡為佳,可能與醋製可增加柴胡皂苷 D的釋出有關。至於製首烏調節血脂異常與體脂肪不易形成的功效與增強肝臟氧化體增殖活化受體 PPARα與脂質氧化酵素 ACO蛋白的表現量均不如生品,可能與黑豆汁拌蒸後會降低藥材大黃素的釋出相關。不論是柴胡及其醋製炮製品或是生首烏與製首烏於本計畫使用劑量下服用十二周均不會造成實驗大鼠肝腎功能的異常。綜合本計畫調控體脂不易形成功效與可能引至肝腎副作用評估的結果,於成人建議治療劑量連續使用十二周,柴胡使用宜應以醋製炮製品為優先考量;生首烏的作用較製首烏為佳。 |
英文摘要 | AIM: The aim of the study were on the evaluation of the effects of herbal medicines such as Chai Hu (Bupleuri Radix) and Ho-Shou-Wu (Polygoni Multiflori Radix), and the processed products that commonly used in hyperlipidemia, on the amelioration of high energy diet-induced obesity in rats. In addition, the possible hepatotoxicity or nephrotoxicity induced by long-term administration of these anti-obesity herbal medicines and its processed products will be evaluated. METHOD: In folk medicine, the recommended daily oral dose of Chai Hu and Ho-Shou-Wu are 3-15 and 10-30 g per adult per day, respectively. The dose of the tested herbal medicine was calculated by multiplying the recommended dose of intake per kilogram by the human metabolism coefficient to get the dose of intake per day of rats. The obesity rats were dosed by oral gavage once per day for 12 weeks with unprocessed Chai Hu and its vinegar-fried product ranged from 0.3-1.5 g/kg. The approximate daily oral dose of Ho-Shou-Wu and Ho-Shou-Wu steamed in black soybean juice (processed Ho-Shou-Wu) for rat is ranged from 1-3 g/kg. The efficacy of the tested herbal medicines on the weight reduction were evaluated by the changes in body weight and white adipocyte weight in obesity rats, as well as the results from the biopsy in white adipocytes during the experimental period. The plasma levels of glutamic pyruvic transaminase and glutamic oxaloacetic transaminase and the levels of blood urea nitrogen and plasma creatinine concentration were determined to evaluate whether the damage on liver or kidney was induced by the tested herbal medicines and the proceed products. The pathological evaluation was further performed to evaluate the pathology of hepatotoxicity and nephrotoxicity. RESULTS & DISCUSSION: The dyslipidemia in obesity rats was improved after being fed unprocessed Chai Hu or its vinegar-fried product for 12 weeks. The unprocessed Chai Hu and its vinegar-fried product also lowered hepatic lipid droplet accumulation and the size of epididymal adipocytes, and caused reductions in lipid peroxidation in HFD-fed rats. The benefit effects of unprocessed Chai Hu and its vinegar-fried product were related with increasing in the expression of hepatic levels of peroxisome proliferators activated receptor (PPAR)α and acetyl-CoA oxidase (ACO). However, the capacity of vinegar-fried Chai Hu on the controlling visceral fat accumulation and related protein expression were more potent than that produced by unprocessed product, which might be related with the releasing of saikosaponian D was enhanced by vinegar-processing. The efficacy of the processed Ho-Shou-Wu on the regulation of dyslipidemia and visceral fat accumulation as well as enhancement on hepatic PPARα and ACO expression was less than those produced by unprocessed product; this might be due to the releasing of emodin was reduced by black soybean juice steaming. Neither the tested herbal medicines nor the processed products caused the hepatotoxicity or nephrotoxicity in HFD-fed rats. It suggested that basing on the recommended daily oral dose, vinegar-fried Chai Hu was taken into the first consideration on controlling visceral fat accumulation comparing to the unprocessed Chai Hu; the efficacy of unprocessed Ho-Shou-Wu on the regulation visceral fat accumulation was potent than that black soybean juice steamed product. The tested herbal medicines and the processed products did not cause the damages on liver and kidney in HFD-fed rats at the recommended daily oral dose after feeding for 12 weeks. |
本系統中英文摘要資訊取自各篇刊載內容。