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題名 | Short-term Outcome of “Watch and Wait” for Rectal Cancer with Clinical Complete Response after Neoadjuvant Chemoradiotherapy="觀察及等待"應用於直腸癌化放療術後合併完全臨床反應的短期成效 |
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作者 | 賴建良; 李家政; 吳昌杰; 李才宇; 饒樹文; 蕭正文; | 書刊名 | 中華民國大腸直腸外科醫學會雜誌 |
卷期 | 26:3 2015.09[民104.09] |
頁次 | 頁109-116 |
分類號 | 416.245 |
關鍵詞 | 化放療; 直腸癌; 完全臨床反應; Chemoradiation therapy; Rectum cancer; Clinical complete response; |
語文 | 英文(English) |
中文摘要 | 目的 “觀察及等待"治療分針對於直腸癌化放療術後合併完全臨床反應是治療上的一個選擇,但是短期成效相關數據不明,本篇目的在評估本院處理相關病患的短期成效。方法 利用病例回顧的方式,我們回朔從2007年1月1日到2013年12月31日這六年間,直腸癌化放療術後合併完全臨床反應者被納入本篇評估。結果 總共有18位病人符合篩選條件,其中14人在接受化放療術後8到12週有接受經肛門切除手術,其餘四位只有接受觀察追蹤。在經肛門切除手術的病人中有兩位發生局部復發,再經歷一次經肛門清除手術也獲得成功治療。平均腫瘤復發時間為69.78個月,五年存活率為100%。三年內的CEA追蹤都在正常範圍。結論 “觀察及等待"治療分針對於存活率及復發率好的成效,建議應用於直腸癌化放療術後合併完全臨床反應的病人。 |
英文摘要 | Purpose. “Watch and Wait" policy would be the option of treatment for locally advanced rectal cancer following chemo radiotherapy with clinical complete response The short-term outcome for“Watch and Wait" has not been well established. The purpose of this work was to assess the short-term outcome of non-operative strategies. Methods. This is an observational retrospective study of one institute. All of the patients with locally advanced rectal cancer following chemo radiotherapy with clinical complete response from January 1, 2007 to December 31, 2013 were included. Results. The study population consisted of 18 patients. 14 patients underwent trans anal wide excision of primary lesion 8-12 weeks later after chemo radiotherapy, and the remaining 4 patients were left for only observation. Two local recurrences occurred in those undergoing trans anal wide excision and were successfully treated by another trans anal wide excision. Average disease-free period was 69.78 months, and 5 year-overall survival rate was 100%. CEA were within normal range in 3 years follow-up. Conclusions. “Watch and Wait" policy offers good results in terms of survival and recurrence rates, and the policy could be be considered a therapeutic option in patients with locally advanced rectal cancer following chemo radiation therapy with complete clinical response. |
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