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- Anti-Jo-1 Antibody in Patients with Polymyositis/Dermatomyositis
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題名 | Clinical Presentations Associated with Anti-Jo-1 Antibody in Patients with Polymyositis and Dermatomyositis=多發性肌炎和皮肌炎病患臨床表現與抗Jo-1抗體之相關性 |
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作者 | 方耀凡; 羅淑芬; 郭昶甫; 何輝煌; 劉烈邦; 陳基益; 余光輝; | 書刊名 | 中華民國風濕病雜誌 |
卷期 | 26:1/2 2012.12[民101.12] |
頁次 | 頁15-22 |
分類號 | 415.762 |
關鍵詞 | 抗Jo-1抗體; 多發性肌炎; 皮肌炎; Anti-Jo-1; Polymyositis; Dermatomyositis; |
語文 | 英文(English) |
中文摘要 | 背景:分析多發性肌炎和皮肌炎病患臨床表現與抗Jo-1抗體之相關性。方法:我們收集長庚醫院2000至2007年之間151位多發性肌炎和皮肌炎病患病歷做回顧性分析。結果:於151位病患中’有80位有做抗Jo-1抗體;於單ー變數分析中發現間質性肺病(p=0.011)、心臓侵犯(p<0.001)、高血壓(p=0.045)及吞嚥困難(p=0.005)有顯著差異;在控制性別後,以多變數回歸分析顯示出現抗 Jo-1抗體病患合併間質性肺病(勝算比:7.49, 95%信賴區間:1.12-49.91, p=0.037)及心臓侵犯(勝算比:9.39, 95%信賴區間:1.34-165.83, p=0.024)比起沒有抗Jo-1抗體病患有達到統計學的差異性;而以存活分析比較出現抗Jo-1抗體病患及沒有抗Jo-1抗體病患並未達到明顯差異(p=0.201)。 結論:帶有抗Jo-1抗體病患與出現間質性肺病和心臓侵犯的臨床症狀有顯著的相關性;但出現抗 Jo-1抗體病患對存活沒有明顯的影響。 |
英文摘要 | Background: Polymyositis and dermatomyositis are idiopathic inflammatory myopathies and anti-Jo-1 is the most common autoantibody found in inflammatory myositis patients. We aimed to demonstrate clinical symptoms and signs related to anti-Jo-1 antibody in patients with polymoyositis and dermatomyositis. Materials and Methods: We retrospectively reviewed medical records of 151 patients with polymoyositis and dermatomyositis in Chang Gung Memorial Hospital from 2000 to 2007.Results: Eighty (53%) of 151 patients had identified anti-Jo-1 antibody. Interstitial lung disease, cardiac involvement, hypertension, and dysphagia were associated with the presence of anti-Jo-1 antibody according to univariate analysis (p=0.011, <0.001, 0.045, and 0.005, respectively). Multivariate analysis, after adjusting for gender, showed that only interstitial lung disease (odds ratio = 7.49, 95% CI = 1.12-49.91, p=0.037) and cardiac involvement (odds ratio = 9.39, 95% CI = 1.34-165.83, p=0.024) were associated with the presence of anti-Jo-1 antibody. Kaplan-Meier survival analysis was not significantly lower in anti-Jo-1 positive patients than that in those without anti-Jo-1 antibody (p=0.201).Conclusion: This study highlights the clinical symptoms and signs related to anti-Jo-1 antibody in polymoyositis and dermatomyositis. Clinical presentation of interstitial lung disease and cardiac involvement were significantly associated with the presence of anti-Jo-1 antibody although anti-Jo-1 antibody had no influence on survival. |
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