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題名 | 評估Ketorolac用於急診腹痛病人=Evaluation of Ketorolac Used in ED Patients with Abdominal Pain |
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作 者 | 吳宗儒; 張意宜; | 書刊名 | 藥學雜誌 |
卷期 | 31:1=122 2015.03[民104.03] |
頁次 | 頁124-129 |
分類號 | 418.2216 |
關鍵詞 | 非類固醇消炎止痛藥; 急診; 腹痛; 消化道潰瘍; 每日處方劑量; Ketorolac; DDD; |
語文 | 中文(Chinese) |
中文摘要 | Ketorolac 注射劑為一在急診廣泛用於中重度疼痛的短期非類固醇消炎止痛藥 (NSAIDs)。NSAIDs 有消化道相關副作用,不應使用於有胃潰瘍病史或有活動性胃 潰瘍的病人。經由不同途徑投予的 NSAIDs,效果並未顯示差異,但注射劑型有較高 的消化道相關副作用。因此本研究以急診腹部疼痛之病人資料,回溯性評估2個月中 ketorolac 注射劑在急診使用的合理性。結果在252位腹痛病人中,ketorolac 注射劑的 處方問題都清楚浮現,包括60歲以上老人使用比率高、劑量未予個別化、使用在有消 化道潰瘍或出血病史的病人、以及和其他藥物的併用等。由於 ketorolac 有潛在的高 風險,因此需增強醫師對使用 ketorolac 注射劑的警覺性,而藥師也應持續的評估, 並協助相關資訊的建置。 |
英文摘要 | Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) widely used in the emergency department (ED) for short-term management of moderate to severe pain. Because of the potentially gastrointestinal adverse effects, NSAIDs used in patients with active or GI ulcer history were considered as contraindications. The analgesic efficacy of NSAIDs was proved to be different by using different administration routes, but the gastrointestinal adverse effects were higher when used parenterally. To recognize the appropriateness of using ketorolac in our ED, we collected the data of patients who diagnosed as abdominal pain and were given ketorolac in ED retrospectively. There were 252 patients included in the 2 months periods. We found that high proportion of ketorolac prescriptions are not used appropriately, including high rates of ketorolac prescription above age 60, dosage was not prescribed individualized, prescribed in patients had GI ulcer history and in patients who currently taking drugs with high GI risk. Moreover, the 5-day readmission rate of patients with GI ulcers history showed a statistical significance compared with patients with no GI ulcers history. Therefore, to raise awareness of ketorolac use in clinical practice, carefully evaluation of the safe use of ketorolac by physician and pharmacist is very important. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。