查詢結果分析
相關文獻
- 皮膚角質細胞經比哆胺處理後對短波紫外線之輻射保護作用
- Studies of the Anti-Cancer Action of Econazole in HumanHL 60 Cancer Cell: G0/G1 Cell Cycle Arrest and Apoptotic Signaling Pathways
- 細胞凋亡作用
- Apoptosis: (2) Characteristics of Apoptosis
- Differential Expression of Cytokine Genes and Apoptosis in Glioma Cell Lines upon Exposure to Bacteria and Lipopolysaccharides
- 癌症治療的新方向:細胞凋亡[apoptosis]觀念的應用
- 細胞凋亡與細胞壞死
- Apoptosis: (1) Overview and Clinical Significance
- Apoptotic Phenomenon of Immune Effector Cells in Autoimmune NZB x NZW F1 Mice
- 細胞凋亡(Apoptosis)於臨床上的應用
頁籤選單縮合
題名 | 皮膚角質細胞經比哆胺處理後對短波紫外線之輻射保護作用=Radioprotective Effects of Pyridoxamine after UVC Exposure in HaCat Cells |
---|---|
作者姓名(中文) | 陳思方; 王守正; 許錦龍; 李意旻; 莊曜禎; 林松水; | 書刊名 | 中華放射線技術學雜誌 |
卷期 | 38:3 2014.09[民103.09] |
頁次 | 頁127-133 |
分類號 | 415.71 |
關鍵詞 | 比哆胺; 梅納褐變反應; 糖化作用終產物; 細胞凋亡; 細胞週期停滯; Pyridoxamine; Maillard reactions; Advanced glycation end products; AGEs; Apoptotic cell death; Cell cycle arrest; |
語文 | 中文(Chinese) |
中文摘要 | 紫外線暴露是皮膚急性發炎及皮膚癌主要發生的原因,維生素B6在人體生理代謝扮演酵素作用中非常重要的輔因子,比哆胺(pyridoxamine)是維生素B家族中的一類,比哆胺具有一些生理活性,包括抗輻射、抗氧化、抑制梅納褐變反應、阻斷糖化作用的終產物的發生、清除自由基及活性羧基物質於糖類和脂類分解過程和金屬離子螯合作用過程中。實驗目的在於評估皮膚角質細胞(HaCat cell)先經比哆胺處理再經短波紫外線暴露後藉由紫殘外線存曲線、劑量反應曲線、流式細胞儀等方法評估其輻射保護效應。結果顯示比哆胺確實可減少UVC所引起的細胞凋亡的比率,由72.9%降低至49.5%。結論顯示比哆胺確實具有輻射保護作用,可能藉由細胞週期停滯與細胞凋亡的路徑所調控。 |
英文摘要 | Ultraviolet irradiation is a major factor to induce an acute inflammation and skin cancer. Vitamin B6 plays as an enzyme cofactor in metabolic processes of human physiology. Pyridoxamine (PM), one type of the vitamin B6 family, it have some chemical properties incIuding radioprotection, inhibition of the Maillard reaction, blocking the formation of advanced glycation endproducts (AGEs), and the scavenging of free radical species and carbonyl species formed in sugar and Iipid degradation and chelation of metal ions that catalyze Amadori reactions. Our study aim is to evaluate radioprotective effects of pyridoxamine after UVC exposure by survival curve, dose response curve and flowcytometry analysis in HaCat cells. The results showed that PM pre-treatment can effectively rescue the UV-induced cell death rate from 72.9% to 49.5%. Pyridoxamine treatment showed to decrease UV. induced apoptotic cell death from. In conclusion, PM have radioprotective effects apparently, it may be mediated through cell cycle arrest and apoptotic pathway. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。