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題 名 | Duloxetine於慢性疼痛之應用=Clinical Use of Duloxetine for Chronic Pain |
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作 者 | 李旻芬; 林梅芳; | 書刊名 | 藥學雜誌 |
卷 期 | 30:4=121 2014.12[民103.12] |
頁 次 | 頁66-72 |
分類號 | 416.5、416.5 |
關鍵詞 | 抗憂鬱藥; 慢性疼痛; Duloxetine; |
語 文 | 中文(Chinese) |
中文摘要 | Duloxetine 是抑制 serotonin (5-HT) 和 norepinephrine (NE) 再吸收的抗憂鬱藥能 緩解多種慢性疼痛。Duloxetine 核准適應症為重鬱症、廣泛性焦慮症、糖尿病周邊神 經痛,臨床上針對於疼痛之研究包括糖尿病周邊神經痛、纖維肌痛、退化性關節炎 導致之肌肉骨骼疼痛和慢性下背痛,層面廣泛且有效。值得進行更多的研究來評估 duloxetine 在臨床中樞神經性疼痛所扮演的調節角色。 |
英文摘要 | Duloxetine causes a balanced inhibition of serotonin (5-HT) and norepinephrine (NE) reuptake. Duloxetine is newer antidepressant that is used to treat several types of chronic pain. Duloxetine is approved to treat major depressive disorder and generalized anxiety disorder, and to manage diabetic peripheral neuropathic pain. In clinical trials, duloxetine has been shown to be effective in treating patients with diabetic peripheral neuropathic pain, fibromyalgia, chronic pain due to osteoarthritis, and chronic low back pain. It would be worthwhile to perform more studies to evaluate the role of duloxetine in modulation of the symptoms of central neuropathic pain. |
本系統中英文摘要資訊取自各篇刊載內容。