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頁籤選單縮合
題名 | Vancomycin低感受性金黃葡萄球菌血症=Bacteremia Caused by Staphylococcus Aureus with Reduced Vancomycin Susceptibility |
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作者 | 郭世武; 陳琦華; 鄧新棠; Kuo, Shih-wu; Chen, Chi-hua; Deng, Shin-tarng; |
期刊 | 藥學雜誌 |
出版日期 | 20131200 |
卷期 | 29:4=117 2013.12[民102.12] |
頁次 | 頁133-138 |
分類號 | 418.281 |
語文 | chi |
關鍵詞 | 金黃葡萄球菌; 菌血症; 抗生素; hVISA; VISA; Vancomycin; Teicoplanin; Linezolid; Daptomycin; |
中文摘要 | 金黃葡萄球菌 (Staphylococcus aureus, S. aureus)是人類重要的致病菌,隨著 vancomycin的普遍使用,研究發現 S. aureus對 vancomycin的感受性越來越差,甚而導致治療失敗。本案例報告描述一住院中發生 VISA (vancomycin intermediate-resistant S. aureus)菌血症病人,在給予 linezolid合併 sodium fusidate、rifampin治療後,膽紅素上升而面臨缺乏合適用藥的狀況。藉著此病人之治療過程,我們探討可用於治療 VISA的抗生素之藥品特性、須注意的副作用、感染 VISA的危險因子等。避免抗藥性 S. aureus的產生是治療疾病之外另一重要課題,平時合理、適當地使用抗生素是藥師可以貢獻專業之處。 |
英文摘要 | Staphylococcus aureus (S. aureus) has been a long standing human pathogen. With the widespread use of vancomycin, the susceptibility of S. aureus to vancomycin was diminished, and even resulted in treatment failure. This case report described a patient who had bacteremia caused by vancomycin/daptomycin intermediate-resistant S. aureus. Linezolid in combination with fusidic acid and rifampin were administered immediately, but then the serum bilirubin rose. The choice among currently available antibiotics for the patient was very limited. In this case report, we tried to investigate the characteristics of antibiotic used in VISA bacteremia、drug related side effects and risk factors of VISA infections. Measure to avoid the emergence of drug resistant S. aureus is another important issue in the treatment of infection. Pharmacist plays an important role in the multidisciplinary team guarding the appropriate use of antibiotics. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。