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題 名 | Impact of Metabolic Syndrome on Health-related Quality of Life and Obesity-related Hormone in Obese Women=代謝症候群對肥胖婦女健康相關生活品質與肥胖相關荷爾蒙之影響 |
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作 者 | 劉佳祐; 陳怡如; 邱榮鵬; 許中華; | 書刊名 | 北市醫學雜誌 |
卷 期 | 10:3 2013.09[民102.09] |
頁 次 | 頁182-194 |
分類號 | 415.593、415.593 |
關鍵詞 | 肥胖; 代謝症候群; 健康相關生活品質; 肥胖相關荷爾蒙; Metabolic syndrome; Health related quality of life; Obesity-related hormone peptides; |
語 文 | 英文(English) |
中文摘要 | 肥胖是近年來與心血管疾病和糖尿病的重要危險因子,也是產生代謝症候群的主因。雖然肥胖與代謝症候群兩者都對於健康相關生活品質有顯著的影響,卻少有研究分析代謝症候群對於健康相關生活品質與肥胖相關荷爾蒙的影響。因此本研究旨在探討在肥胖婦女身上代謝症候群指標對於健康相關生活品質與肥胖相關荷爾蒙的影響。方法:本研究納入259位身體質量指數(BMI)≥27 kg/m^2以及腰圍≥80公分的婦女,所有受試者至少符合一項美國國家膽固醇教育計畫成人治療指引第三版的代謝症候群診斷條件,本研究將評估分析受試者的基本生命徵象、健康相關生活品質(WHOQOL-BREF)、以及insulin、leptin、ghrelin、adiponectin等多項荷爾蒙。結果:相較於未診斷代謝症候群的受試者,150位代謝症候群的肥胖婦女具有較低的健康相關生活品質生理指標、較低的adiponectin,以及較高的leptin與ghrelin。隨者代謝症候群指標數的增加,健康生活品質生理指標與adiponectin有下降的趨勢,而insulin、胰島素阻抗性、ghrelin則有上升的趨勢。這些指標變化均達到統計學上的顯著差異。(p<0.001,except p=0.025 for ghrelin)。至於其他參數並未隨著代謝症候群指標數的增加而有所變化。結論:合併代謝症候群的肥胖婦女具有較差的生理方面健康相關生活品質。代謝症候群指標對於健康生活品質生理指標與adiponectin可能具有負向的影響,需要未來針對健康相關生活品質與肥胖相關荷爾蒙進一步談討。 |
英文摘要 | Obesity is an important health issue and risk factor in the development of cardiovascular disease and type 2 diabetes mellitus. It is also an underlying cause of metabolic syndrome (MS). Both obesity and MS have significant impact on health-related quality of life (HRQOL). Few studies have assessed the relationship between MS, HRQOL, and obesity-related hormone peptides in obese women. The present study investigated the impact of MS components on HRQOL and obesity-related hormone peptides in obese women. Methods: This study enrolled 259 obese women with body mass index (BMI) ≥ 27 kg/m^2 and waist circumference ≥ 80 cm. Their anthropometric characteristics, biochemical characteristic, HRQOL, and obesity-related hormone peptides including insulin, leptin, ghrelin, and adiponectin were evaluated. All subjects met at least one of the five MS components defined in the National Cholesterol Education Program, Adult Treatment Panel III. Results: Obese women with MS (n = 150) had lower HROQL in physical domain, lower level of adiponectin, but higher level of leptin and ghrelin than those without. With increasing number of MS components, lower HRQOL in physical domain, lower adiponectin, higher insulin, insulin resistance, and ghrelin were noted with statistical significance in the linear trend test (all p < 0.001, except p = 0.025 for ghrelin). Leptin and other domains of HRQOL were not associated with the number of MS components. Conclusions: Obese women with MS had worse physical aspect of HRQOL than those without. The negative impact of MS components on physical aspect of HRQOL and adiponectin in obese women was noted. Future studies should focus on the relationship between HRQOL and obesity-related hormone peptides. |
本系統中英文摘要資訊取自各篇刊載內容。