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題名 | Ticlopidine引起之肝炎--文獻回顧=Ticlopidine-Induced Cholestatic Hepatitis |
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作者姓名(中文) | 陳弘益; | 書刊名 | 藥學雜誌 |
卷期 | 29:3=116 2013.09[民102.09] |
頁次 | 頁106-110 |
分類號 | 418.23 |
關鍵詞 | 肝炎; 藥物不良反應; Ticlopidine; Hepatitis; Adverse drug events; |
語文 | 中文(Chinese) |
中文摘要 | 背景:Ticlopidine 屬於抗血小板藥物,具不可逆抑制血小板凝集的作用,用於降低中風風險。通常保留給不適合使用 aspirin 的病人或以 aspirin 治療失敗的病人,另一主要適應症是降低冠狀動脈支架病人的血栓併發症風險。副作用有 neutropenia (初期會發熱、喉嚨痛、疲倦感等症狀),血栓性血小板減少性紫斑,黃疸,噁心嘔吐、皮膚癢、變黃,及食慾不振、胃不舒服等和肝炎。 目的:本文以文獻回顧了解 ticlopidine 可能引起的肝炎症狀、種類、原因、處置及注意事項,藉以改善病人用藥安全。 結果:搜尋「台灣臨床藥學雜誌 肝炎」、「藥學雜誌 肝炎」,未搜尋到台灣文獻。Pubmed 共搜尋到33篇適當文獻,膽汁鬱積型肝炎佔23篇 (69.69%),未提及何種肝炎佔七篇 (21.21%),肉芽腫樣肝炎佔兩篇 (6.06%),肝細胞損傷型佔一篇 (3.03%),無非洲人種的報導。 結論:Ursodeoxycholic acid、silymarin,曾被用來治療 ticlopidine 引起的肝損傷。Ticlopidine 引起的肝損傷通常需數星期或數月才能恢復,藥師若能對肝臟損傷的偵測與評估及誘發藥物有深入的了解,提醒病人,才能及時發現藥品產生肝臟毒性,及時降低傷害,提升用藥安全。 |
英文摘要 | Ticlopidine is an irreversible platelet aggregation inhibitor used to reduce the risk for thrombotic stroke. Use of this drug is typically reserved for patients who are intolerant to aspirin, and for those whose aspirin therapy has failed. The other primary indication for use is to reduce the incidence of thrombotic complications in patients with coronary stents. Ticlopidine has been associated with life-threatening hematologic disorders, including neutropenia (initial symptoms include fever, sore throat, and fatigue), thrombotic thrombocytopenic purpura, jaundice, nausea, vomiting, itching, yellow skin, poor appetite and stomach upset. This article is meant to understand ticlopidine-induced each kind of symptoms, causes, management and precautions of hepatitis with literature review. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。