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題 名 | 疑似Diclofenac誘發的溶血性貧血=Suspected Diclofenac-Induced Hemolytic Anemia |
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作 者 | 溫學琴; 汪曉嵐; 吳美慧; 賴慧如; | 書刊名 | 藥學雜誌 |
卷 期 | 29:3=116 2013.09[民102.09] |
頁 次 | 頁96-100 |
分類號 | 418.224 |
關鍵詞 | 藥物誘發溶血性貧血; 藥物不良反應; Diclofenac; |
語 文 | 中文(Chinese) |
中文摘要 | 藥物誘導溶血性貧血為不常見卻嚴重的副作用,抗生素、非固醇類解熱鎮痛劑、oxaliplatin、α-methyldopa 等皆為造成藥物誘導溶血性貧血常見的藥物。此個案使用 diclofenac 後血色素及血容比驟降,幸即時停藥及處理,預後良好。Diclofenac 誘導溶血嚴重者可導致急性腎衰竭、瀰漫性血管內凝集、休克甚至死亡,然而 diclofenac 為一廣泛被使用的藥品,文獻亦提出 diclofenac 誘發的溶血性貧血難與暖型抗體 (warm-reactive autoantibodies) 造成的自體免疫溶血性貧血區分而造成誤診,在此概述藥物誘發溶血性貧血的分類與機轉,藉此提醒醫療同業留意此不良反應。 |
英文摘要 | Drug-induced immune hemolytic anemia is a rare but a serious adverse reaction. Antibiotics, nonsteroidal anti-inflammatory drug, oxaliplatin, alpha-methyldopa etc are the drugs that most frequently cause immune hemolytic anemia. The case of a 33-year-old woman who developed Hb/Ht dropping sharply after treated with diclofenac (25 mg) prn used for fever. Diclofenac was discontinued and the patient was treated with ferrous and folic acid. She was discharged in good prognosis. Diclofenac induced immune hemolytic anemia in severe case may cause acute renal failure, disseminated intravascular coagulation, shock and even be fatal. Diclofenac is a widely used nonsteroidal anti-inflammatory drug. Nevertheless, it cause hemolytic syndrome very similar to autoimmune hemolytic anemia of warm type. In this review, the pathogenic mechanisms and types of drug induced immune hemolytic anemia for reminding the medical staff to be careful to the adverse drug reactions. |
本系統中英文摘要資訊取自各篇刊載內容。