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題名 | 治療晚期腎細胞癌之口服標靶治療藥物:Everolimus=Everolimus: The Oral Targeted Therapy Drugs for Treating Late-stage Renal Cell Carcinoma |
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作者姓名(中文) | 蘇郁仁; | 書刊名 | 腫瘤護理雜誌 |
卷期 | 13:1 2013.06[民102.06] |
頁次 | 頁21-25 |
分類號 | 418.22 |
關鍵詞 | 腎細胞癌; 標靶藥物; Renal cell carcinoma; Targeted therapy drugs; Everolimus; |
語文 | 中文(Chinese) |
中文摘要 | 在台灣,腎細胞癌約占所有惡性腫瘤的3%,由於初期症狀不明顯,發現通常已是晚期,因而面臨無藥可用的窘境。以往治療大多以免疫療法為首選,但近來以分子標靶治療藥物治療腎臟癌已逐漸成形。Everolimus的作用機轉便是藉由抑制mTOR蛋白,進一步抑制腫瘤細胞的分化生長與血管新生。此藥物不良反應包括口腔潰瘍、感染、無力、疲勞、腹瀉、咳嗽等,期許可搭配不同作用機轉的藥物,以做為治療腎細胞癌的選擇。 |
英文摘要 | Renal cell carcinoma is about 3% among all malignant tumors in Taiwan. Because the symptoms are not obvious during the early stage, but usually found at the late stage, and thus encounter the dilemma of no drugs available. Formerly, the treatment preferred using the immunotherapy. However, recently the treatment is inclined to use the molecular target therapy for late-stage renal cell carcinoma Everolimus, a mammalian target of rapamycin (mTOR) protein inhibitor, which further inhibit tumor cell growth and differentiation of angiogenesis, is the first choice. For the patients with hepatic function impairment, dosage adjustment is necessary. The common adverse drug reactions include mouth ulcers, infections, weakness, fatigue, diarrhea, and cough. The health care providers need to inform patients of the possible adverse drug reactions, and of the combined use with different mechanisms of action of the drugs. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。