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題名 | 菊科及大戟科植物抗發炎活性分析及篩選=Analysis and Screening of Anti-inflammatory Activity on Compositae and Euphorbiaceae Plants |
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作者 | 羅英妃; 王靜瓊; 李美娟; Lo, Ying-fei; Wang, Ching-chiung; Lee, Mei-jiuan; |
期刊 | 植物種苗 |
出版日期 | 20130300 |
卷期 | 15:1 2013.03[民102.03] |
頁次 | 頁53-66 |
分類號 | 435.435 |
語文 | chi |
關鍵詞 | 菊科植物; 大戟科植物; 細胞毒性; 抗發炎活性; Compositae; Euphorbiaceae; Cytotoxicity; Anti-inflammatory activity; |
中文摘要 | 本研究以19種菊科植物及18種大戟科植物之50%甲醇萃取物 來進行生物活性分析。實驗結果顯示,利用細菌脂多醣誘發鼷鼠 RAW264.7細胞產生NO之抑制發炎活性評估,在參試之菊科植物中, 以台灣款冬之抗發炎活性最佳,約92.56%,其抑制NO生成的IC50為 27.59 昭/ml。對於癌細胞株(T24、HeLa及HepG2)之細胞毒性指數值 (CI% )分別為14.68%、3.67%及37.82%,對正常細胞(3T3細胞株)之細 胞毒性指數值約30%。在參試之大戟科植物中,以白飯樹之抗發炎活 性佳,約74.42%,且不會影響RAW264.7巨噬細胞之存活率,對癌細 胞株T24、HeLa及HepG?之毒性較低,僅分別為25.54%、30.73%及 35.33%,但其對正常細胞(3T3細胞株)具有強烈細胞毒性,細胞毒性指 數值約96.6% ,綜合上述結果,台灣款冬及白飯樹具有較佳之抗發炎活性,未來若欲開發利用,仍需進行相關毒性試驗評估。 |
英文摘要 | In this study, 19 kinds of Compositae and 18 kinds of Euphorbiaceae plants were extracted by 50% MeOH for bioactivity assay. The anti-inflammatory activity of plant extracts was performed by the inhibition of lipopolysaccharide-induced NO production in RAW264.7 macrophages. Petasites formosanus Kitamura had the highest antiinflammatory activity (about 92.56%) of Compositae plants tested. However, it showed cytotoxicity on normal cell line (3T3) (CI% about 30%), but not on cancer cell lines (T-24, HeLa, and HepG2, (CI% are 14.68%、3.67% and 37.82%, respectively). In Euphorbiaceae plants extracts, Fluggea virosus Roxb. Willd had the higher anti-inflammatory activity(about 74%) of plants evaluated, this plant also showed strong cytotoxicity on normal cell line (3T3) (CI% about 96.6%), but not on cancer cell lines (T-24, HeLa, and HepG2) (CI% are 25.54%、30.73% and 35.33%, respectively). In according to the above results, Petasites formosanus Kitamura and Fluggea virosus Roxb. Willd had great anti-inflammatory activity, but the toxicity should be concerned for the development in the future. |
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