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題名 | 荷葉乙醇萃取物及其正丁醇區分層對以高熱量飲食誘導SD大鼠不易形成體脂肪之影響及其DNA微陣列分析=Anti-obesity Effect of Ethanolic Extract and Butanol Fraction from Lotus Leaves on SD Rats Fed with High Energy Diets and Its DNA Microarray Analysis |
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作者 | 林弘育; 鍾成沛; 江文章; Lin, Hong-yu; Chung, Cheng-pei; Chiang, Wenchang; |
期刊 | 臺灣農業化學與食品科學 |
出版日期 | 20121000、20121100、20121200 |
卷期 | 50:5/6 2012.10-12[民101.10-12] |
頁次 | 頁239-248 |
分類號 | 411.3 |
語文 | chi |
關鍵詞 | 荷葉; 高熱量飲食; 肥胖; DNA微陣列分析; Lotus leaves; High energy diet; Obesity; DNA microarray analysis; |
中文摘要 | 本試驗目的在探討荷葉乙醇萃取物及其正丁醇區分層對以高熱量飲食誘導SD大鼠不易形成體脂肪功效,並以DNA微陣列分析探討攝食荷葉正丁醇區分層對高熱量飲食動物肝臟基因表現之影響。試驗分為六組,每組八隻。分別為餵食purina 5001之正常組、高熱量飲食組(HE)、高熱量飲食外添加4.0%荷葉乙醇萃取物組、高熱量飲食外添加0.5%、1.0%與2.0%正丁醇區分層組。結果顯示餵食高熱量飲食八週後會造成體重與脂肪組織之累積,給予2.0%正丁醇區分層可顯著抑制脂肪組織之累積與降低血糖及胰島素之濃度,另外肝臟與血清中三酸甘油酯含量亦顯著降低。由微陣列資料顯示出荷葉正丁醇區分層抑制體內脂肪組織之累積與降低血清、肝臟中三酸甘油酯含量可能是經由活化脂肪酸氧化作用所造成,另外給予2.0%正丁醇區分層改善因高熱量飲食導致葡萄糖吸收不良與改善因肥胖導致高胰島素血症,與正調控glycolysis及insulin signalling途徑之基因相關。 |
英文摘要 | The aim of this study was to investigate the anti-obesity effect of ethanolic extract (LLE) and butanol fraction (LLEB) from lotus leaves on SD rats fed with high energy diets. Furthermore, the hepatic gene expression from rats ingested with 2.0% LLEB was analyzed by DNA microarray. SD rats were randomly divided into six groups (n=8). Male SD rats were fed with a Purina 5001 diet (control group), a high energy diet (HE group), a high energy diet with 4.0% LLE and high energy diets with 0.5, 1.0, 2.0% LLMB, respectively. The results revealed that a high energy diet administered to SD rats for 8 weeks led to significant increase of body and adipose tissue weight. Ingestion of 2.0% LLEB inhibited the development of increased blood glucose, insulin concentration and abdominal fat mass, while plasma and hepatic triglyceride concentrations were significantly lower in the 2.0% LLEB group than in the HE group. The microarray analysis of hepatic mRNA indicated that 2.0% LLEB up-regulated the expression of genes related to fatty acid oxidation, probably resulting in the suppression of the elevation of triglyceride concentration and abdominal fat mass. Expression of genes related to glycolysis and insulin signaling was also up-regulated in the 2.0% LLEB group suggesting that administration of LLEB could ameliorate obesity-induced hyperinsulinemia as well as the decrease of blood glucose. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。