查詢結果分析
相關文獻
- Allogeneic Related Bone Marrow Transplantation in Children--A Single Center Experience
- 臺北縣特殊教育三年專業團隊運作模式之成果
- Child Transitional Object Attachment: Nature, Development, and Related Factors
- 散布性交易訊息刑罰化合憲否
- 阿美族歌謠運用在兒童樂隊對學生音樂學習成果之行動研究
- 兒童知覺動作發展
- 聯合國與盧安達人權:滅絕種族及其他罪行之懲治
- 學齡前兒童之聽力篩檢
- Strokes in Children: A Medical Center-Based Study
- 兒童癲癇重積狀態
頁籤選單縮合
題名 | Allogeneic Related Bone Marrow Transplantation in Children--A Single Center Experience=兒童親屬間異體骨髓移植:單一醫學中心之經驗 |
---|---|
作者 | 陳世翔; 洪悠紀; 楊兆平; 江東和; 方恩真; 楊淑賀; 曾振淦; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷期 | 46:6 民94.11-12 |
頁次 | 頁352-355+405 |
分類號 | 417.653 |
關鍵詞 | 親屬間異體骨髓移植; 成果; 兒童; Allogeneic related bone marrow transplantation; Outcome; Children; |
語文 | 英文(English) |
英文摘要 | We report our single-center experience with related allogeneic bone marrow transplantation (BMT) in pediatric recipients between April 1998 and December 2004. Allogeneic bone marrow grafts from 19 donors (18 human leukocyte antigen (HLA)-matched sibling donors and 1 one antigen-mismatched related donor) were transplanted into patients aged 3-17 years (16 with leukemia and 3 with non-malignant disease). The patients received a cell dose, with median total nucleated cell dose of 3.9×10^8/kg (range, 0.7-8.7×10^8) and median CD 34(superscript +) cell dose of 3.0×10^6/kg (range, 0.3-9.8×10^6). Seventeen patients (89.4%) engrafted after a median of 19 days (range 14-20 days). Acute graft versus host disease (GVHD) grade Ⅱ to Ⅳ developed in 8 patients (42.1%), and limited chronic GVHD developed in 2 evaluable patients (10.5%). Twelve of the 19 patients were alive at a median follow-up of 1460 days (range, 270-2260 days). Full chimeric hematopoiesis was maintained in 11 of these 12 patients. Six patients (31.6%) had relapse of their underlying malignant disease, and one of them is still alive. Seven patients died (5 because of relapse and/or disease progression and 2 because of infectious complication). The underlying diseases were acute lymphoblastic leukemia (ALL; 4 cases: 3 CR2, 1 Ph+), acute myeloid leukemia (AML; 2 cases: 1 CR2, 1 refractory), and juvenile chronic myelogenous leukemia (JCML; 1 case). Relapsed leukemia at an extramedullary site occurred in 2 patients with ALL after BMT. Although our data should be interpreted cautiously considering the limited number of patients, isolated extramedullary relapse seems to be common after allogeneic BMT. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。