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題 名 | Effects of Repeated Acupuncture on Peak Expiratory Flow Variation and Serum Eosinophil Cationic Protein Concentration in Asthmatic Patients=重複針灸刺激對氣喘病患尖峰吐氣流速變異性的改變與嗜伊紅性球陽離子蛋白濃度的影響評估 |
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作 者 | 林聖哲; 朱國安; 許健威; 林旻希; 吳宜瑾; 王鴻昌; 丁燿明; 賴瑞生; | 書刊名 | 胸腔醫學 |
卷 期 | 28:3 2013.06[民102.06] |
頁 次 | 頁138-146 |
分類號 | 415.425 |
關鍵詞 | 針刺; 氣喘; 發炎; 肺量計; Acupuncture; Asthma; Inflammation; Spirometry; |
語 文 | 英文(English) |
中文摘要 | 背景:針刺引起的支氣管擴張的機轉過去並不是很清楚。這個前瞻性隨機交叉研究旨在藉由應用嗜伊紅性球陽離子蛋白,一種氣喘的發炎因子,來確認重複針刺所造成的可能抗發炎效果及臨床和生理上的好處。方法:30個病人於3週內以隨機單盲方式安排接受實際針刺及假針刺。所有病人在經過3週的廓清期後交叉。我們記錄了實際針刺及假針刺前後的嗜伊紅性球陽離子蛋白濃度、肺計量、尖峰吐氣流速變異性的改變、及支氣管擴張劑的使用頻率。結果:27個病患完成試驗。實際針刺後,第1秒用力吐氣量、血清嗜伊紅性球陽離子蛋白濃度、尖峰吐氣流速變異性的改變及支氣管擴張劑的使用頻率皆有顯著改善。(p<0.05)。結論:氣喘病患接受重複針刺後有較佳的血清嗜伊紅性球陽離子蛋白濃度改變與臨床生理反應。 |
英文摘要 | Background: The mechanism involved in acupuncture's immediate bronchodilating effects remains unclear. This prospective randomized crossover controlled study aimed to determine the possible anti-inflammatory effects and clinical and physiologic benefits of repeated acupuncture using serum eosinophil cationic protein (ECP), an indicator of asthmatic inflammation.Methods: Thirty asthmatic patients were randomly assigned to initially receive real acupuncture (RA) or sham acupuncture (SA) for 3 weeks in a blinded manner. Each patient was then crossed-over with a 3-week wash-out period. The ECP, spirometry, variation of peak expiratory flow rate (PEFR) and frequency of rescue bronchodilator use of each patient were recorded before and after RA and SA.Result: The 27 patients who completed the trial showed significant improvements in post-RA forced expiratory volume in 1 second, serum ECP concentration, variation of PEFR, and frequency of rescue bronchodilator use compared to post-SA (p<0.05).Conclusion: Asthmatic patients who received repeated acupuncture had improvements in ECP and better clinical and physiologic responses. |
本系統中英文摘要資訊取自各篇刊載內容。