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題名 | 休葛蘭氏徵候群=Sjögren's Syndrome |
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作者姓名(中文) | 吳素芳; 楊瑛碧; | 書刊名 | 藥學雜誌 |
卷期 | 28:3=112 2012.09[民101.09] |
頁次 | 頁91-95 |
分類號 | 415.695 |
關鍵詞 | 休葛蘭氏徵候群; 乾燥症候群; Sicca features; Muscarinic agonist; Sjögren's syndrome; Rituximab; |
語文 | 中文(Chinese) |
中文摘要 | 休葛蘭氏徵候群 (Sjögren's syndrome, SS) 又稱為乾燥症候群。是一種慢性進行性自體免疫疾病,主要破壞人體的外分泌腺,以唾腺和淚腺為主,臨床上又可分為原發性和續發性兩種,原發性 SS 的臨床表現最常見為口腔、眼睛乾燥並伴隨唾液腺腫大,腺體外也可能侵犯皮膚、關節、腎臟、神經系統等。續發性 SS 常併存其他自體免疫疾病,如類風濕性關節炎。目前以症狀治療為主,擬膽鹼作用劑 (cholinergic agents) 可用於治療病人乾燥的症狀 (sicca features),免疫抑制劑和生物製劑用來治療腺體外的症狀。本文主要介紹原發性休葛蘭氏徵候群及其治療現況。 |
英文摘要 | Sjögren's syndrome is a chronic progressive autoimmune disease that mainly presents with sicca symptomatology of mucosal surfaces, mainly dry mouth and dry eyes. There is often systemic involvement of skin, joints, kidney etc (extraglandular manifestations) and lymphoma is a recognized complication. Sjögren's syndrome can occur alone (primary SS) or concomitantly suffer from other autoimmune diseases such as rheumatic diseases (secondary SS). Treatment of SS is mainly the symptomatic relief and to confirm the diagnosis and to treat the complications of the disease as soon as possibly. Muscarinic agonists has been used for xerostomia and keratoconjunctivitis sicca effectively, while the immunosuppressive/biological agents are for extraglandular features. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。