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題名 | Haptoglobin Genotypes Correlate with the Survival of Patients with Colorectal Cancer=回溯性探討Haptoglobin Genotype與非轉移之大腸癌之存活情形之關聯性 |
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作者 | 賴泓誌; 陳宜鈞; 魏昌國; 林宏益; 余芝嘉; 李思錦; 洪世凱; 周明智; 蘇裕傑; | 書刊名 | 臺灣癌症醫學雜誌 |
卷期 | 28:2 2012.06[民101.06] |
頁次 | 頁68-75 |
分類號 | 416.245 |
關鍵詞 | 血紅素結合蛋白; 大腸直腸癌; 存活率; Haptoglobin; Colorectal cancer; Survival rate; |
語文 | 英文(English) |
中文摘要 | 目的:本研究旨在研究血紅素結合蛋白之基因多型性與大腸直腸癌之病人存活情形之關 聯性。 方法及資料:本研究收集單一教學醫院之大腸直腸癌病患並抽血保存於 EDTA 管中,進 一步使用逆轉錄聚合酶鏈式反應確認血紅素結合蛋白之基因型。考量治療及臨床病情之 複雜性而排除第四期之大腸直腸癌病人。 結果:從西元 2005 年 1 月至 11 月共計 62 個非轉移性大腸直腸癌病患接受血紅素結合蛋 白基因型之分析檢驗。因病例數太少排除五個 Hp 1-1 及二個 Hp 2-0 病人,最後分析了 29 個 Hp 2-1 及 27 個 Hp 2-2 病人。根據年齡及腫瘤分期進行配對分析後發現具有 Hp 2-2 之 病人其整體存活率較差(Hazard ratio (HR) 3.0; p = 0.028) 且疾病特定之存活較差(HR 3.5; p = 0.018)。 結論:本研究證實 Hp 2-2 基因型與非轉移性的大腸直腸癌病患之較短的整體存活以及疾 病特定之存活情形有顯著相關。具有 Hp 2-2 基因型之非轉移性的大腸直腸癌病患的預後 較差。 |
英文摘要 | To investigate a possible association between haptoglobin (Hp) genotypic variation and the development of colorectal cancer (CRC), we evaluated cases of patients diagnosed with CRC at our hospital. Healthy individuals were selected at random as controls. Hp genotypes were analyzed using polymerase chain reaction. There was no difference in the distribution of Hp genotypes between patients with CRC and healthy individuals. The CRC patients were evenly matched with respect to age and tumor stage for analysis of the Hp genotype. Patients with the Hp 2-2 genotype had significantly worse overall survival (Hazard ratio (HR) 3.0, p = 0.028) and disease-specific survival rates than patients with the Hp 2-1 genotype (HR 3.5, p = 0.018). Results of this study demonstrated that the pattern of Hp genotype distribution in CRC patients is the same as in healthy individuals. Hp genotype may influence the survival of non-metastatic CRC patients. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。