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題名 | 自然生物標靶--測量細胞死亡及幹細胞分化過程之新陳代謝=Intrinsic Biomarker for the Detection of Cell Death and Stem Cell Metabolism during Its Differentiation |
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作者 | 王興雯; | 書刊名 | 光學工程 |
卷期 | 118 2012.06[民101.06] |
頁次 | 頁1-6 |
分類號 | 415.1157 |
關鍵詞 | 自然生物標靶; 幹細胞分化; 低劑量光動力治療劑量學; Intrinsic biomarker; Stem cell differentiation; Metronomic photodynamic therapy; |
語文 | 中文(Chinese) |
中文摘要 | 此篇文章介紹本實驗室在過去幾年來研究一個可能的自然生物標靶NADH自體螢光用於偵測細胞死亡及幹細胞分化過程中的新陳代謝程度。本人研究偵測細胞死亡自然生物標靶的動機來自低劑量光動力治療劑量學中偵測生物反應的需求。然而在這個研究過程中,我們發現這個自然生物標靶偵測也可能延伸用於其他的細胞死亡偵測,進而應用到疾病的偵測。在了解訊號變化來源的同時,我們發現其和幹細胞分化過程中的新陳代謝有很好的正向關條,也成為偵測幹細胞分化很好的自然標靶。 |
英文摘要 | This article introduces our series of researches in finding a potential intrinsic biomarker NADH to detect cell death and stem cell differentiation. The motivation of detecting cell death noninvasively is from metronomic photodynamic therapy which induced more apopotosis than necrosis. During our series of researches, we found NADH fluorescence can be used for other cell death detection and applied in disease diagnosis. We also found the change of NADH fluorescence is positively correlated with cellular metabolism during stern cell differentiation. This result indicates that NADH fluorescence is a potential biomarker of stem cell differentiation. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。