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頁籤選單縮合
| 題 名 | Successful Management of Probable Imatinib- Related Pneumonitis in a Gastrointestinal Stromal Tumor Patient without Discontinuing Imatinib--A Case Report and Literature Review=未停用Imatinib即成功治療一胃腸道間質腫瘤病患之疑似Imatinib相關肺炎--病例報告與文獻回顧 |
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| 作 者 | 魏伯儒; 楊志仁; 黃吉志; 鍾飲文; 黃明賢; 張肇松; | 書刊名 | 胸腔醫學 |
| 卷 期 | 27:5 2012.10[民101.10] |
| 頁 次 | 頁311-317 |
| 分類號 | 415.4、415.4 |
| 關鍵詞 | 肺炎; 類固醇; Imatinib; Pneumonitis; Steroid; |
| 語 文 | 英文(English) |
| 中文摘要 | Imatinib是一種用於治療慢性骨髓性白血病及胃腸道間質腫瘤的酪胺酸激酶抑制劑。Imatinib相關肺炎很少被報告,尤其在胃腸道間質腫瘤的病人中。我們報告一名五十三歲胃腸道間質腫瘤的男性病患因十天內漸進式之呼吸困難被轉至本院,他因低血氧的情形而需要氧氣治療。胸部X光及電腦斷層檢查顯示雙側沿支氣管血管束分布之肺實質化變化。在藥物相關肺炎的臆斷下,他接受了類固醇治療。雖然imatinib並未被停用,他呼吸困難的情形在類固醇治療下逐漸改善,在十天內即不需要氧氣供應,而胸部X光上也發現明顯的改善。據我們所知,這是文獻上第一次報告在胃腸道間質腫瘤病人的疑似imatinib相關肺炎未停用imatinib即成功治療之案例。這樣的案例顯示藥物相關肺炎有機會在沒有停用相關藥物的狀況下仍能治療成功。 |
| 英文摘要 | Imatinib is a tyrosine kinase inhibitor that is used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumor (GIST). Imatinib-related pneumonitis has been rarely reported, especially in GIST patients. A 53-year-old man with GIST treated with imatinib for 9 months was referred to our hospital because of progressive exertional dyspnea for 10 days. He developed hypoxemia and required oxygen supply. Chest radiograph and computed tomography revealed bilateral consolidations with peri-bronchovascular bundle distribution. Under the impression of probable drug-related pneumonitis, he was treated with systemic steroid. Although imatinib was not discontinued, his dyspnea improved gradually and he became independent of the oxygen supply within 10 days. The chest radiograph confirmed substantial improvement. To our knowledge, this is the first case of probable imatinib-induced pneumonitis in a GIST patient that was managed efficiently with steroid without discontinuing imatinib. This case demonstrates the possibility of successful management of drug-related pneumonitis without discontinuing the offending drug. |
本系統中英文摘要資訊取自各篇刊載內容。