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相關文獻
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題名 | ST-Segment Elevation Acute Myocardial Infarction after 5-Fluorouracil Infusion=5-氟脲嘧啶低注後發生急性ST段升高心肌梗塞 |
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作者 | 謝佳訓; 蘇柏榮; 謝建安; 楊嘉浤; 廖宗琦; | 書刊名 | 臺灣癌症醫學雜誌 |
卷期 | 28:1 2012.03[民101.03] |
頁次 | 頁28-34 |
分類號 | 418.31 |
關鍵詞 | 5-氟脲嘧啶; 急性ST段升高心肌梗塞; 化學治療; 右側灌種動脈; 食道癌; 5-fluorouracil; ST-segment elevation myocardial infarction; Chemotherapy; Right coronary artery; Esophageal cancer; |
語文 | 英文(English) |
中文摘要 | 我們報告了一例五十三歲的食道癌患者接受過含有 5-氟脲嘧啶(5-fluorouracil)的放化 療(chemoradiotherapy)之後,經歷了右側冠狀動脈完全阻塞的急性 ST 斷升高心肌梗塞。 本文當中亦展示了冠狀動脈攝影之證據來證實這個診斷。此現象是相當地重要因為它是 會致命的。真正5-氟脲嘧啶相關的心肌梗塞是非常的少,但是對於臨床腫瘤科醫師與心臟 科醫師來說卻是相當地重要。本文亦回顧了過去相關的文獻,尤其是病理研究、發生機 率與血液中藥物濃度與發生的關係。對於5-氟脲嘧啶後嚴重心血管併發症現象,我們急需 要更多、更深入的病生理研究。 |
英文摘要 | We report a 53-year-old male patient with esophageal spindle cell carcinoma undergoing 5-fluorouracil-containing chemoradiotherapy who experienced an episode of acute ST-segment elevation myocardial infarction. There was angiographic evidence of a total occlusive lesion of the right coronary artery. This kind of severe cardiovascular adverse effect, potentially lethal, is an important complication. True acute myocardial infarction after 5-fluorouracil-based chemotherapy is extremely rare but should be borne in mind as a possibility in clinical cardiologic and oncologic practice. In this article, we have also reviewed appropriate articles in the literature with regard to pathologic findings, incidence and plasma concentration. Further investigation on the pathophysiology of severe cardiovascular events related to 5-FU administration is urgently needed. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。