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| 題 名 | 抗結核藥物用藥疏失引起肝毒性之案例報告與改善方案分享=The Improvement of Medication Error Associated with Anti-Tuberculosis Drugs Inducing Hepatotoxicity |
|---|---|
| 作 者 | 顧曉耘; 李安凰; 羅仁美; | 書刊名 | 藥學雜誌 |
| 卷 期 | 28:2=111 2012.06[民101.06] |
| 頁 次 | 頁121-125 |
| 分類號 | 418.2219 |
| 關鍵詞 | 抗結核病藥物; 肝毒性; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 抗結核藥物常引起無症狀的肝指數上升,當肝指數持續上升而導致嚴重肝毒性,若未能及時診斷和處置,可成為致命的副作用,即使未能造成致命的副作用,病人也可能因副作用所產生的不適而自行中斷藥物治療,造成治療失敗或疾病的復發,甚至導致抗藥性的產生。 給予抗結核病藥物時,應以體重來斟酌給藥劑量,監測相關數值,方可減少肝毒性的產生和其產生後的影響。本案為用藥疏失導致藥物劑量過高所引起之肝毒性,因此本篇除了探討抗結核藥物引起肝毒性之處置外,亦利用魚骨圖分析找出其用藥疏失發生之根本原因,並分享本院建構之預防措施。 |
| 英文摘要 | Asymptomatic serum transaminase elevations are common during ant-tuberculosis (anti-TB) dugs treatment. Continuous elevation of transaminase may lead to severe hepatotoxicity. It can be fetal when not diagnosed early and when therapy is not introduced in time. Patients may interrupt the pharmacotherapy by themselves due to the uncomfortable adverse effect. It probably contributes to the therapy failure, relapse, and drug resistance. While treating TB, we ought to calculate the dosage by body weight (BW) and monitor the hepatitis–related lab data. In our case, the overdose induced hepatotoxicity was caused by medication error. Therefore, not only do we discuss the treatment of anti-TB drugs induced hepatotoxicity, but also investigate the root causes of the medication error. In the end, we will share the prevention methods of the medication error. |
本系統中英文摘要資訊取自各篇刊載內容。