頁籤選單縮合
題名 | 腫瘤溶解症候群的預防與治療=Prevention and Management of Tumor Lysis Syndrome |
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作者 | 許育瑋; 蔡佩芬; 林慧娟; | 書刊名 | 藥學雜誌 |
卷期 | 28:2=111 2012.06[民101.06] |
頁次 | 頁84-89 |
分類號 | 415.138 |
關鍵詞 | 腫瘤溶解症候群; 急性腎衰竭; Tumor lysis syndrome; TLS; Rasburicase; |
語文 | 中文(Chinese) |
中文摘要 | 腫瘤溶解症候群 (tumor lysis syndrome, TLS) 是由於腫瘤細胞快速的被破壞,使原本細胞內各種離子、核酸、蛋白質和代謝物,突然大量且快速釋放到細胞外所導致的嚴重代謝性異常,通常發生於接受化學治療的腫瘤細胞開始大量死亡及細胞內容物溶解之後,主要與腫瘤的體積、腫瘤細胞溶解的程度及患者的種類有關,對於具有高增生速率、高腫瘤負擔以及對化療具高度敏感性的腫瘤,都是發生 TLS 的高危險群。 TLS 主要的預防及治療措施包括水分的補充、校正電解質與腎衰竭的支持性治療;除給予適當的預防與治療措施外,亦須密集的監控電解質變化,必要時應採取更積極的治療措施。TLS 所產生的併發症會影響化學治療的效果甚至後續治療的進行,發生後若沒有即時且適當的治療介入,嚴重時甚至可能造成死亡,因此早期的辨別、預防及治療可以降低這些致死性併發症發生的機會。 |
英文摘要 | Tumor lysis syndrome (TLS) is a category of metabolic derangements which caused by the massive and rapid release of cellular constituents into the systemic circulation after the rapid lysis of malignant cells. The syndrome is seen most frequently after large amount of cell lysis in patients who exposed to cytotoxic therapy. Malignancies with high proliferative rate, large tumor burden, or high sensitivity to cytotoxic therapy are generally considered at high risk of TLS. The major interventions include hydration, metabolic abnormalities correction, and supportive treatment of renal failure. Electrolyte levels should also be monitored closely, and aggressive treatment should be taken if necessary. Complications resulting from TLS may influence the efficacy or further treatment of chemotherapy, and may cause death without immediate and adequent interventions. Early recognition, prevention and treatment can decrease the risk of those fatal complications. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。