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| 題 名 | Obesity and Cancer Risk: Hypothesis of Competing Causes=肥胖與癌症風險--競爭成因的假說 |
|---|---|
| 作 者 | 郭家甫; 祝年豐; 趙祖怡; | 書刊名 | 臺灣癌症醫學雜誌 |
| 卷 期 | 27:6 2011.12[民100.12] |
| 頁 次 | 頁237-241 |
| 分類號 | 415.138、415.138 |
| 關鍵詞 | 肥胖; 癌症; 危險因子; Obesity; Cancer; Risk factors; |
| 語 文 | 英文(English) |
| 中文摘要 | 近三十年來,惡性腫瘤在開發中或已開發國家國家常位居十大死因的前三位,不但 是醫療保健的重要課題,也是公共衛生的重大挑戰之ㄧ。 惡性腫瘤的危險因子包括抽菸、喝酒、嚼食檳榔、不良飲食習慣、放射暴露及感染 等生活作息與環境暴露因素。許多流行病研究發現,肥胖個案其惡性腫瘤死亡率較非肥 胖者為高。肥胖與某些特定內分泌相關惡性腫瘤(如:女性子宮內膜癌、卵巢癌與男性食道 癌、甲狀腺癌、大腸直腸癌等)的發生有密切相關。 然而肥胖造成惡性腫瘤的可能機轉仍不是十分清楚,包括肥胖造成發炎反應,脂肪 組織的功能異常造成脂肪細胞激素(adipocytokines)分泌異常,肥胖造成內源性胰島素或性 荷爾蒙功能異常等都是可能機轉。 因此,本報告將從流行病學觀點,來探討肥胖在惡性腫瘤的風險及其所扮演的角色 作一綜合分析。 |
| 英文摘要 | Recent evidence suggests an important association between obesity and several cancers. However, the possibility of a causal relationship between obesity and cancer, and competing risk factors are also being investigated. As such, several mechanisms have been proposed for different obesity-cancer pathways. In addition, the benefits of cancer patient weight loss and physical activity have also been noted. As the ramifications of obesity and overweight adults continue to provide challenges to our society, increasing attention is warranted to more comprehensively investigate the association between cancer and obesity. |
本系統中英文摘要資訊取自各篇刊載內容。