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題名 | Tc-99m SPECT Corrections between Cameras Using a Phantom Study=以Tc-99m單光子造影假體分析造影儀間相關性 |
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作者 | 蔡季蓉; 廖美秀; 鄭澄意; 葉啟斌; 沈立漢; 張嘉容; 陳家杰; 諶鴻遠; 黃文盛; | 書刊名 | 核子醫學雜誌 |
卷期 | 24:1 2011.03[民100.03] |
頁次 | 頁2-6 |
關鍵詞 | 假體; 一致性; 變異性; Tc-99m TRODAT-1; Phantom; Correlation; Variation; |
語文 | 英文(English) |
中文摘要 | 前言:Tc-99m TRODAT-1製劑已廣泛在國內臨床應用,但不同儀器及單位間的影像判讀及標的物範圍設定方式仍有其差異性及限制。本研究即以腦假體建立Tc-99m腦紋狀體假體造影最佳參數,觀察兩次測試差異性以及評估不同儀器間相關性。方法:本研究以特殊腦部紋狀體假體,在劑量活性相似於臨床狀況下;採紋狀體/背景值為2:1及5:1的Tc-99m濃度獲得Tc-99m SPECT特異攝取值在0.8到3情況下進行三部造影儀(GE, Helix, Hawkeye及Infinia)與實際假體所得關心標的活性經加瑪計數器予以量化後的相關性分析並以t-test及Pearson's相關係數作比較及兩次測試的再現性分析。其中;Helix及Hawkeye採Metz瀘波器而Infinia則採Butterworth瀘波器進行影像處理,結果除以肉眼觀察外亦進行量化分析。結果:在給予特定Tc-99m活性範圍內加瑪計數器與不同造影儀(GE, Helix, Hawkeye及Infinia)間均顯示良好一致性;Tc-99m SPECT特異攝取值在此三部造影儀與實際假體活性相關性分別為:y=0.8401x-1.2148,r2=0.9332;y=0.8091x-0.9414,r2=0.9133及y=0.4687x-0.3525,r2=0.8678。造影儀間亦有良好一致性(r2均大於0.88)。在測試間變異性評估上;不同特異攝取比值,在不同造影儀的紋狀體、尾核及殼核變異範圍均介於0至9.4%,平均變異性則均<5%。其中;Infinia的特異攝取值變化梯度(斜率)較Helix及Hawkeye者低,而後兩者的線性變化梯度則幾近一致。結論:就腦紋狀體造影而言;不同造影參數會影響影像結果,但由於腦部紋狀體及其次區域影像特異攝取值與實際活性計數值以及不同造影儀間有良好線性關係與低影像再現變異性;因此,臨床上如能獲得不同造影儀間相關係數則可彼此作量化判讀。 |
英文摘要 | Background: Imaging dopaminergic system using Tc-99m TRODAT-1 single photon emission tomography (SPECT) in the human brain appeared feasible and useful for clinical implications. Problems remain including a communicable imaging interpretation between cameras in or inter hospitals. This study was thus intended to observe such possible differences and corrected parameters between cameras using an established brain phantom method.Methods: A specially designed phantom for brain ST imaging was applied. Tc-99m radioactivity used in this study were adjusted similar to that of clinical use with original filling ratios for ST and background ranged from 2:1 to 5:1 that created imaging specific uptake ratios [SURs] ranged from 0.8 to 3. Thee types of gamma cameras (GE, Helix Hawkeye and Infinia) were applied with optimal imaging acquisitions and analyses respectively, where Metz filter used in Helix and Hawkeye and Butterworth in Infinia. The actual radioactivity in ST and background was measured by a gamma counter. Imaging test-retest variations were calculated. The linear regression was applied for correlations of radioactivity between cameras.Results: Good correlations of radioactivity were found between the gamma counter and the SURs measured from the 3 gamma cameras in given ranges, i.e. y=0.8401x-1.2148, r^2=0.9332 for Helix; y=0.8091x-0.9414, r^2=0.9133 for Hawkeye and y=0.4687x-0.3525, r^2=0.8678 for Infinia. Acceptable correlations were also achieved between Helix and Hawkeye but fair to Infinia. The test-retest variations of ST and its subregions among cameras ranged 0% to 9.4% with an average of <5%.Conclusions: Striatal imaging display could differ due to used parameters. However, the acceptable imaging variations and good correlations between in vivo/in vitro radioactivity and that in different cameras suggested that, for practice, Tc-99m striatal SPECT can be quantitatively interpreted and compared in different sites if correlative factors between cameras were set. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。