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題名 | Nasal-type Extranodal Natural Killer (NK)/T-Cell Lymphoma Presenting with Primary Mucocutaneous Lesions Mimicking Behcet Disease=鼻型淋巴結外的自然殺手/T細胞淋巴癌以原發性黏膜皮膚病灶類似貝西氏病來表現 |
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作者 | 蔡瑞鴻; 陳雅萍; | 書刊名 | 臺灣癌症醫學雜誌 |
卷期 | 27:3 2011.06[民100.06] |
頁次 | 頁133-137 |
分類號 | 415.6 |
關鍵詞 | 鼻型淋巴結外的自然殺手/T細胞淋巴癌; 貝西氏病; Nasal-type extranodal NK/T-cell lymphoma; Behcet disease; |
語文 | 英文(English) |
中文摘要 | 鼻型淋巴結外的自然殺手/T細胞淋巴癌以類似貝西氏病來表現乃是相當罕見的。本病例報告為一位53歲男性,初期是以多處的口腔及會陰處皮膚黏膜等處之潰瘍來表現。此病患之自體免疫疾病相關之抗核抗體血清學檢查呈現陰性,但是卻帶有HLA-B51。口腔黏膜切片顯示白細胞破碎性血管炎。而系列追蹤胸部X 光片顯示病人肺部有多處腫塊。進一步透過肺部組織切片檢查,證實為鼻型淋巴結外的自然殺手/T細胞淋巴癌。確定診斷之後病患立即接受全身化學治療,但最後仍死於腫瘤惡化及肺炎。對於這種快速惡化的癌症, 及早診斷與治療是相當重要的。 |
英文摘要 | Mucocutaneous ulcers mimicking Behcet disease as the initial presentations of nasal-type extranodal natural killer (NK)/T-cell lymphoma (ENKTCL) are rare. We report a case of 53-year-old male with initial presentations of multiple mucocutaneous ulcers in the oral and genital areas. Serology tests for autoimmune disease (e.g. anti-nuclear antibody) were all negative except for expression of HLA-B51. Biopsy of buccal mucosa showed leukocytoclastic vasculitis. The follow-up chest plain films showed multiple lung nodules, biopsy of which revealed nasal-type ENKTCL. The patient received systemic chemotherapy as soon as the diagnosis was confirmed but died of lymphoma progression and pneumonia within one month of diagnosis. Early diagnosis and treatment are important due to ENKTCL’s highly aggressive clinical course. |
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