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題 名 | Clozapine併用Fluvoxamine引起痙攣發作案例報告=Seizure Associated with Combination Therapy of Clozapine and Fluvoxamine--Case Report |
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作 者 | 黃士欣; 徐藝珊; 詹永騰; | 書刊名 | 藥學雜誌 |
卷 期 | 27:4=109 2011.12[民100.12] |
頁 次 | 頁127-132 |
分類號 | 418.21 |
關鍵詞 | 痙攣發作; 藥物交互作用; 藥物不良反應; Clozapine; Fluvoxamine; |
語 文 | 中文(Chinese) |
中文摘要 | 本文報告的兩個案例皆是長期在精神專科醫院住院之病人,因在同時服用 clozapine 與 fluvoxamine 後,發生一級藥物交互作用,其機轉為 fluvoxamine 抑制 clozapine 之主要肝臟代謝 CYP 1A2 途徑,促使 clozapine 血中濃度升高,誘發非預期癲癇發作,造成如眼睛上吊、全身痙攣、意識喪失等症狀。經調整 clozapine 劑量並加抗癲癇藥物後病人則未再癲癇發作,本文則為據此整理藥物交互作用之報告及藥物不良反應相關性評估後所作之案例報告。 |
英文摘要 | These two cases were long term inpatients of psychiatric hospital, and had grand mal seizure attack unexpectedly after combination therapy of clozapine with fluvoxamine. Theoretically, they are competition of hepatic CYP 1A2 enzyme, and may increase clozapine serum levels, which may induce seizure, with symptoms of eyes upgaze, convulsions, loss of consciousness, etc. Seizure did not relapse after decreasing dosage of clozapine and adding on anticonvulsants. Therefore, we reported these drug-drug interaction and assessment of adverse reaction. |
本系統中英文摘要資訊取自各篇刊載內容。