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題 名 | 阻塞型睡眠呼吸中止症與心血管疾病血液標誌之分析=Blood Surrogate Markers of Cardiovascular Disease in Obstructive Sleep Apnea |
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作 者 | 宋秉珏; 劉博仁; 曾紀汝; 郭志宏; 陳伯中; | 書刊名 | 臺灣耳鼻喉頭頸外科雜誌 |
卷 期 | 46:5 2011.09-10[民100.09-10] |
頁 次 | 頁241-246 |
分類號 | 415.472 |
關鍵詞 | 阻塞型睡眠呼吸中止症; 心血管疾病; Obstructive sleep apnea; Cardiovascular disease; |
語 文 | 中文(Chinese) |
英文摘要 | BACKGROUND: To evaluate the relationship between obstructive sleep apnea (OSA) and non-hemodynamic mechanisll1 that could cause cardiovascular disease, including inflammatory, coagulation, and oxidative stress mechanisms.METHODS: In this study, we included 29 adults diagnosed with sleep-disordered breathing. Patients with a history ofhypel1ension, cardiovascular disease, cerebrovascular disease, hyperlipidemia, diabetes mellitus, or smoking were excluded. The patients' blood samples were collected in the next morning after performing nocturnal polysoml1ography (PSG) and fasting for at least 8 hours. We examined the blood levels of superoxide dismutase (SOD), glutathione peroxidase and malondialdehyde as oxidative stress markers of cardiovascular disease, high sensitivity C-reactive protein (hsCRP) as an inflammatory marker, and morning fibrinogen as a coagulation marker. In addition, we measured the blood levels of total cholesterol, triglyceride and glucose AC. Before performing nocturnal PSG, the patients' body mass index was measured and Epworth sleepiness scale was determined. Statistical analysis was conducted to determine the relationship between these factors and the apnea-hypopnea index (AHI).RESULTS: In the AHI < 5 group, blood SOD level was 303.11 ± 62.37 U/ml , blood hsCRP level was 0.055 ± 0.048 mg/ml, and blood morning fibrinogen level was 337.4 ± 71.2 mg/ml. In the AHI ≧ 5 group, blood SOD level was 241.17 ± 27.58 U/ml, blood hsCRP level was 0.252 ± 0.203 mg/ml, and blood morning fibrinogen level was 439.4 ± 94.4 mg/ml. In the 5 ≦ AHI < 15 group, blood SOD level was 245.9 ± 24.1 U/ml, blood hsCRP level was 0.18 ± 0.13 mg/ml, and blood morning fibrinogen level was 414.2 ± 80 .6 mg/ml. In the 15 ≦ AHI < 30 group, blood SOD level was 241 ± 30.9 U/ml, blood hsCRP level was 0.3 ± 0.2 mg/ml, and blood morning fibrinogen level was 427 ± 66.3 mg/ml. There were statistically significant difference in blood SOD, hsCRP and morning fibrinogen levels between AHI < 5 and AHI ≧ 5 groups (p < 0.05). Among AHI < 5, 5 ≦ AHI < 15 and 15 ≦ AHI < 30 groups, there were statistically significant difference in blood SOD, hsCRP and morning fibrinogen levels between AHI < 5 and 15 ≦ AHI < 30 groups (p < 0.05). There were also statistically significant difference in blood SOD and morning fibrinogen levels between AHI < 5 and 5 ≦ AHI < 15 groups (p < 0.05).CONCLUSION: Obstructive sleep apnea causes oxidative stress, chronic inflammation, and hypercoagulability from non-hemodynamic mechanism, with which the increased probability of cardiovascular disease in patients with OSA in the future could be associated. |
本系統中英文摘要資訊取自各篇刊載內容。