頁籤選單縮合
題名 | 靜脈注射雙磷酸鹽類藥物引致全葡萄膜炎:病例報告=Panuveitis after Intravenous Injection of Bisphosphonate: A Case Report |
---|---|
作者 | 尤稚凱; 李思慧; 周正亮; | 書刊名 | 臺灣復健醫學雜誌 |
卷期 | 39:3 2011.09[民100.09] |
頁次 | 頁187-193 |
分類號 | 418.2183 |
關鍵詞 | 雙磷酸鹽類; 全葡萄膜炎; 唑來磷酸; Bisphosphonate; Panuveitis; Zoledronic acid; |
語文 | 中文(Chinese) |
中文摘要 | 隨著人類壽命的延長,骨質疏鬆症已是重要的流行病,其常見結果是容易發生各部位之骨折。關於骨質疏鬆症的處理除了定期追蹤骨密度外,還包括:(1)增加飲食中鈣質和維他命D的攝取,(2)保持體重、避免菸酒、規律運動、預防跌倒,(3)藥物方面目前最廣爲使用的則是雙磷酸鹽類藥物(bisphosphonate)。雙磷酸鹽類藥物以抑制蝕骨細胞活性來減少骨質流失,已被廣泛使用在老化所造成的骨質疏鬆、類固醇導致之骨質疏鬆、以及癌症骨頭轉移造成的骨質流失和血鈣過高。此類藥物多半能讓病人廣爲接受,然而還是有許多副作用出現,如:腸胃道不適、低血鈣、肌肉骨骼痠痛、以及少見的眼部發炎。本病例爲60歲女性,因體檢發現有高血膽固醇及骨質缺乏而接受雙磷酸鹽類藥物靜脈注射治療,注射四天後出現右側眼部嚴重疼痛、視力下降、視野所見呈現紫色及灰影等症狀。先至眼科醫院求診,裂隙燈檢查呈現右眼前房有角膜後沉積增加、發炎細胞增加等,而診斷爲右側前葡萄膜炎。其它實驗室檢查,包括免疫學檢查,並未發現其它可能引致此病情之異常。在無其它可能致病因下,此病患被診斷爲靜脈注射唑來磷酸後引致之眼部發炎。 |
英文摘要 | As human life expectancy has increased, osteoporosis has become a major epidemic disorder. The most common consequences of this are fractures in different parts of the body. In addition to regular follow-up tests of bone-mineral density, treatment methods include: 1. increasing the dietary intake of calcium and vitamin D, 2. maintenance of body weight, avoiding alcohol and tobacco, regular exercise, and fall prevention, 3. medications, the most widely used being bisphosphonates. Bisphosphonates can limit bone loss via the inhibition of osteoclasts. They have been widely prescribed for senile osteoporosis, osteoporosis due to administration of steroids, bone loss due to malignancies with bone metastasis, and hypercalcemia. Though they are widely accepted, there are still some reported adverse effects, such as gastro-intestinal discomfort, hypocalcemia, musculoskeletal pain, and ocular inflammation, though the latter is rarely seen.We report the case of a 60-year-old female with a history of hypercholesteremia and osteopenia, which was noted after a recent general physical examination. She exhibited severe pain in the right eye and deterioration of visual acuity with black and purple shadows, after an intravenous injection of zoledronic acid four days prior. Examination with a slitlamp showed fine keratic precipitations in the cornea of the right eye and numerous cells in the anterior chamber with flares. This led to a diagnosis of acute panuveitis of the right eye. The laboratory examination, including immunological tests, did not reveal other possible causes of panuveitis. Since there were no other possible causes of panuveitis, Zoledronic acid-associated ocular inflammation was diagnosed. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。