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頁籤選單縮合
題名 | Valproate與Ertapenem併用引起交互作用之案例報告=Drug Interactions between Valproate and Ertapenem |
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作者姓名(中文) | 楊慧珠; 羅仁美; | 書刊名 | 藥學雜誌 |
卷期 | 27:2=107 2011.06[民100.06] |
頁次 | 頁121-125 |
分類號 | 418.21 |
關鍵詞 | 抗癲癇藥物; 藥物交互作用; Valproate; Ertapenem; Drug interaction; |
語文 | 中文(Chinese) |
中文摘要 | 癲癇症是一種腦部神經細胞重覆發生突然過度放電導致的臨床現象,致病原因以自發性或不明原因為主,其次為頭部損傷、中樞神經感染、中風、產前損傷及腦部腫瘤等。本篇案例要討論的是一位中風後癲癇的安養院住民,多年來以 valproate和 phenytoin控制癲癇情況良好,因肺部及泌尿道感染住院,給予抗生素 ertapenem治療,治療後第 4天、病人癲癇發作,懷疑是 valproate與 ertapenem合併使用而引起的藥物交互作用, ertapenem會誘導 valproate血中濃度下降而造成癲癇發作,該病患經由更改抗生素後其症狀即獲得改善。 |
英文摘要 | Seizures are the clinical manifestation of sudden abnormal electrical discharge of cortical neurons. It can arise spontaneously or from an unknown cause; other causes include head injury, CNS infections, or lesions, cerebrovascular accidents, related to pregnancy. We want to present a case of a patient recently living under the care of a nursing home, diagnosed previously with post stroke seizure. Her seizure had been controlled for many years with valproate and phenytoin as medications. The patient had been confined to a hospital recently for respiratory and urinary tract infection, empirical treatment with IV antibiotics ertapenem started. After 4 days of antimicrobial therapy, seizure developed. We are considering this seizure as a drug-drug interaction induced by concomitant use of ertapenem IV antimicrobial with valproate . Ertapenem cause a decrease in serum level of valproate triggering a seizure episode. After shifting to other antimicrobial, improvement noted, the patient did not develop any seizure episodes. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。