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題 名 | 疑似Ceftriaxone引起嬰兒過敏性休克=Suspected Ceftriaxone-induced Anaphylactic Shock in an Infant |
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作 者 | 陳弘益; 唐正乾; 蔡佩瑜; | 書刊名 | 藥學雜誌 |
卷 期 | 27:2=107 2011.06[民100.06] |
頁 次 | 頁96-100 |
分類號 | 418.281 |
關鍵詞 | 嬰兒; 過敏性休克; 不良反應; Ceftriaxone; |
語 文 | 中文(Chinese) |
中文摘要 | Ceftriaxone穿透血腦屏障,進入腦脊髓液的能力良好,用於嬰兒的腦膜炎 (meningitis)之經驗性療法,也用於治療急性中耳炎 (acute otitis media)、無併發症的淋病、軟性下疳 (chancroid)、急性副睪炎 (acute epididymitis)。全國不良反應通報中心自 88年度到 96年度的統計資料中,前十名可疑藥物, ceftriaxone並未在列。然而搜尋國外之報告,有一篇文獻指出早產兒因 ceftriaxone而發生過敏性休克,國外另一篇是關於新生兒因 ceftriaxone而發生過敏性休克,一位兒童因 ceftriaxone發生過敏性反應 3,另一篇是成人因 ceftriaxone發生過敏性反應。我們所報告的是一位十月大男嬰,因為疑似靜脈注射 ceftriaxone,出現低血壓,上半身發紅的過敏性休克,在給予生理食鹽水補充體液、抗組織胺及類固醇治療後得到緩解。本文提出疑似靜脈輸注 ceftriaxone引起嬰兒過敏性休克,不只是因為病患在輸注完 ceftriaxone發生過敏性休克,也因為先前在他院已經有疑似 ceftriaxone過敏史,因此提醒醫療人員,盡早發現並紀錄藥品不良反應的重要性,藉以防止病人遭受可能的二次傷害。 |
英文摘要 | Ceftriaxone well penetrates the blood-brain barrier into the cerebrospinal fluid. It is not only empirical therapy for the baby's meningitis , but also for the treatment of acute otitis media, gonorrhea without complications, soft chancre, acute epididymitis. Data from the national reporting system of adverse drug reactions in Taiwan revealed that ceftriaxone was not in the top ten suspected drugs that caused adverse reactions from 1999 to 2007. However, in foreign literature reports, they mentioned that one preterm baby, one child and one adult went into anaphylactic reaction because of ceftriaxone. We reported a ten-month-old baby boy who suffered hypotension, anaphylactic shock and red upper body after intravenous ceftriaxone. The baby became well after saline rehydration, antihistamine and steroid treatment. We suspected that intravenous infusion of ceftriaxone resulted anaphylactic shock in this infant, not only because the baby got shock after intravenous infusion of ceftriaxone but also because of possible ceftriaxone allergy history when the baby was in other hospital. Medical staffs in other hospital seemed not mention about it. So we alert the medical staffs about the importance of early detection and recording adverse drug reaction to prevent patient from possible second harm. |
本系統中英文摘要資訊取自各篇刊載內容。