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題 名 | Daptomycin用於細菌性骨關節炎之案例報告=Daptomycin Treatment in a Patient with Septic Arthritis |
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作 者 | 蕭詩如; 吳企華; 王堯顯; | 書刊名 | 藥學雜誌 |
卷 期 | 27:2=107 2011.06[民100.06] |
頁 次 | 頁63-67 |
分類號 | 418.281 |
關鍵詞 | 細菌性關節炎; Daptomycin; Methicillin-resistance Staphylococcus aureus; MRSA; |
語 文 | 中文(Chinese) |
中文摘要 | Daptomycin是 cyclic lipopeptide類,屬於濃度依賴型 (concentration-dependent killing)的殺菌性抗生素,主要抗菌範圍為革蘭氏陽性菌,包括 methicillin-resistance Staphylococcus aureus (MRSA),FDA核准之適應症為革蘭氏陽性菌感染所造成的複雜性皮膚和皮膚組織感染及 Staphylococcus aureus 引起之菌血症併發右側心內膜炎。本案例為 56歲 MRSA感染的細菌性骨關節炎男性,使用 vancomycin及 teicoplanin產生過敏而改用 daptomycin治療之案例,藉由此案例探討並回顧文獻 daptomycin用於細菌性骨關節炎之療效及安全性,以供臨床治療用藥參考。 |
英文摘要 | Daptomycin is a cyclic lipopeptide with concentration-dependent killing and bactericidal against Gram-postive cooci including MRSA. The drug was approved by the Food and Drug Administration (FDA) for the treatment of complicated skin and skin structure infections and Staphylococcus auerus bacteremia including right-sided endocarditis. We report a 56-yearold male was diagnosed with septic arthritis due to MRSA. Vancomycin and teicoplanin therapy for the patient was terminated due to allergy and change to daptomycin. In this article we performed a review of literature to evaluate the effectiveness and safety of daptomycin therapy in septic arthritis. |
本系統中英文摘要資訊取自各篇刊載內容。