查詢結果分析
相關文獻
- Predictors of Non-remission for Antidepressant Treatment among the Elders with Major Depressive Disorder: A Preliminary Open-label Study
- 新型抗憂鬱劑
- 高齡人力資源發展
- 抗憂鬱劑對性功能之影響與處置
- 醫學中心非精神科門診病人處方SSRIs:Fluoxetine與Paroxetine之回溯性使用評估
- 抗憂鬱劑對心血管影響之探討
- 高齡人口住宅需求趨勢與規劃之研究
- 九十年代憂鬱症的藥物治療--目前的成果及未來的發展
- 抗憂鬱劑的副作用
- Fluoxetine的藥物交互作用
頁籤選單縮合
題名 | Predictors of Non-remission for Antidepressant Treatment among the Elders with Major Depressive Disorder: A Preliminary Open-label Study=老人憂鬱症抗憂鬱劑治療未緩解之預測因子:一個初步的開放式研究 |
---|---|
作者姓名(中文) | 吳易澄; 葉怡君; 顏如佑; 柯志鴻; 顏正芳; 陳正生; | 書刊名 | Taiwanese Journal of Psychiatry |
卷期 | 25:2 2011.06[民100.06] |
頁次 | 頁99-105+126 |
分類號 | 415.985 |
關鍵詞 | 高齡人; 老人憂鬱症; 抗憂鬱劑; Elderly; Late-life depression; Antidepressant; |
語文 | 英文(English) |
英文摘要 | Background: Treatment for depressive elders is a challenge due to the complexity in clinical manifestation, medical comorbidity and etiologies. There has been scant of the literature regarding treatment outcomes and their correlates among the elderly patients with major depressive disorder at acute stage in Taiwan. We conducted a preliminary 12-week open-labeled trial of antidepressants for the late-life major depressive disorder, and examined the predictors of patients with poor outcome. Methods: Sixty elderly patients with late-life major depressive disorder were recruited for a 12-week open-labeled study of acute antidepressants treatment. Depressive severities were assessed using 17-item Hamilton Depression Rating Scale for Depression (HAMD17) at weeks, 0, 2, 4, 8, and 12-week. Treatment remission were defined by HAMD17 ≦7 and Clinical Global Inventory (CGI) ≦2. Antidepressants were prescribed according to clinical judgment. The intent-to-treat population using the last observation carried forward (LOCF) method was used for analysis. Results: Among the patients achieving remission during the trial, the proportions of remitted patients of each visit were: 15.4% at the 2-week, 23.1% at the 4-week, 50% at the 8-week, and 11.5% at the 12-week. We found that the elderly patients with late-onset of first major depressive episode, higher scores of mood factor, and sleep factor were likely to be non-remitted from antidepressant treatments. Conclusions: In this study, only 40% of elder patients could complete 12-week acute antidepressant treatments. Near half of all study participants reached remission. In summary, late-onset of the disease, severe depressed mood, and sleep disturbances could be the predictors for non-remission. But the study results need to be validated in future studies with larger sample sizes in the numbers of the study subjects as well as group comparation and randomization in design. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。