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題名 | Comparison between 0.08% Ropivacaine and 0.06% Levobupivacaine for Epidural Analgesia during Nulliparous Labor: A Retrospective Study in a Single Center=比較0.08%耐樂品(Ropivacaine)與0.06%開洛凱因(Levobupivacaine),合併使用0.0002%吩坦尼(Fentanyl)在初產婦硬脊膜外之止痛:單一醫院之回溯性研究 |
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作者姓名(中文) | 李慧玲; 羅良明; 周宗川; 蔡榮財; | 書刊名 | 長庚醫誌 |
卷期 | 34:3 2011.05-06[民100.05-06] |
頁次 | 頁286-292 |
分類號 | 417.372 |
關鍵詞 | 硬脊膜外止痛; 耐樂品; 開洛凱因; Epidural analgesia; Ropivacaine; Levobupivacaine; |
語文 | 英文(English) |
英文摘要 | Background: Levobupivacaine and ropivacaine are new local anesthetics that have effects similar to bupivacaine. However, the relative potency of these two drugs is controversial. The purpose of this retrospective study was to assess whether a combination of 0.06% levobupivacaine and 0.0002% fentanyl had the same effects as 0.08% ropivacaine and 0.0002% fentanyl on the mode of delivery and other obstetric outcomes when used for epidural analgesia of labor in nulliparous women. Methods: Computer records of 392 Asian nulliparous parturients, who had presented with spontaneous labor or spontaneous rupture of the membranes, and had received epidural analgesia were retrospectively reviewed. Of these, 193 received 0.08% ropivacaine and 199 received 0.06% levobupivacaine. Fentanyl (0.0002%) was used in both regimens. Results: There were no significant differences in the mode of delivery, duration of labor, or neonatal outcome between the two groups. In the levobupivacaine group, the parturients required top-up boluses of local anesthetics more frequently (1.4 1.6 vs. 0.9 1.3, p < 0.0001), and the incidence of temporary maternal fever (25% vs. 15%, p = 0.024) and the cost of local anesthetic were higher (292 183 NTD vs. 146 104 NTD, p < 0.0001). However, the amount of local anesthetic administered during labor was lower (79 49 mg vs. 114 81 mg, p < 0.0001) than for the ropivacaine group. Conclusions: 0.06% levobupivacaine was as effective as 0.08% ropivacaine, when both were used with 0.0002% fentanyl for labor epidural analgesia of nulliparous women. |
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