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題名 | 抗痙攣藥物用於開顱手術後癲癇發作治療案例探討=Anticonvulsant Drugs in the Treatment of Seizure Attack after Craniotomy--Case Report |
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作 者 | 陶育村; | 書刊名 | 藥學雜誌 |
卷期 | 27:1=106 2011.03[民100.03] |
頁次 | 頁75-82 |
分類號 | 418.21 |
關鍵詞 | 抗痙攣藥物; 創傷後的痙攣發作; Antiepileptic drugs; Posttraumatic epilepsy; |
語文 | 中文(Chinese) |
中文摘要 | 顱內出血合併開顱手術的病人是產生癲癇發作的高危險群之一,頭部外傷或手術後的癲癇發作會更加重腦部繼發性的損害。 Phenytoin與valproic acid常用於治療各種類型的癲癇與痙攣發作,由於其屬於療效濃度範圍狹窄的藥品,在臨床使用上需要密切監測血中濃度以達到良好的治療效果。本案例係報導一位 54歲男性病患,因顱內出血入院進行顱內手術,術後出現反覆痙攣發作的情形。 |
英文摘要 | Intracranial hemorrhage with craniotomy is a high risk for patient to induce seizure attack. Head injury or post-operation epilepsy may enhance the secondary damage of brain. Phenytoin and valproic acid are usually used to treat various kinds of seizures. Because of its narrow therapeutic range, it is needed to closely monitor its plasma level for a better therapeutic effect in clinical use. This case reported that a 54 years old man was admitted for emergent craniotomy for spontaneous intracranial hemorrhage and seizure attack repeatedly occurred after surgical operation. |
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