頁籤選單縮合
題 名 | Selective Stability-Indicating Methods for the Determination of Clonidine Hydrochloride and/or Its Related Substance, 2,6-Dichloroaniline=具選擇性且穩定之鹽酸可樂定檢測方法 |
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作 者 | Haggag, Rim Said; Belal, Saied Fathalla; Shaalan, Rasha Abdel-aziz; | 書刊名 | Journal of Food and Drug Analysis |
卷 期 | 19:2 2011.06[民100.06] |
頁 次 | 頁174-182+241 |
分類號 | 418.1 |
關鍵詞 | 鹽酸可樂定; 2,6-二氯苯胺; 衍生物比率分光光度學; 一階衍生物分光光度法; Clonidine hydrochloride; 2,6-dichloroaniline; Derivative-ratio spectrophotometry; First derivative spectrophotometric method; N-ethylenediamine; 1-naphthyl ethylenediamine; |
語 文 | 英文(English) |
英文摘要 | Three rapid, sensitive and selective analytical methods were developed for the determination of clonidine hydrochloride and its related substance: 2,6-dichloroaniline in a mixture of both. The first method depends on derivative-ratio spectrophotometry where the first derivative signals of the ratio spectra at 228.4 nm (Δλ = 2 nm) were selected to determine clonidine hydrochloride. The second method is based on measuring the first derivative response of 2,6-dichloroaniline at 300.8 nm with no interference from intact clonidine hydrochloride. In the third method, 2,6-dichloroaniline was determined via diazotization and coupling with N-(1-naphthyl) ethylenediamine to yield a colored azo dye which was measured at 498 nm. Various parameters affecting each method were studied and optimized. The proposed methods were validated according to USP guidelines concerning linearity, ranges, accuracy, precision, detection and quantification limits. The derivative-ratio spectrophotometric method was applied to the analysis of clonidine hydrochloride in tablets and the results were found in good agreement with those of the USP XXX HPLC procedure, while both the second and third methods permitted the selective analysis of 2,6-dichloroaniline in clonidine hydrochloride raw material. |
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