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題名 | Role of Nitric Oxide in the Development of Vascular Contractile Dysfunction in Circulatory Shock=一氧化氮在循環性休克時血管收縮功能失常過程中的角色 |
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作者姓名(中文) | 吳錦楨; | 書刊名 | Journal of Medical Sciences |
卷期 | 31:1 2011.02[民100.02] |
頁次 | 頁1-16 |
分類號 | 415.149 |
關鍵詞 | 一氧化氮; 敗血性休克; 血管舒張; 中樞神經系統; Sepsis; cGMP; Nitric oxide; Superoxide; Circulatory shock; |
語文 | 英文(English) |
英文摘要 | Various forms of circulatory shock (including septic shock) lead to an impairment of vascular function, which importantly contributes to the development of multiple organ failure and mortality. The dysfunction of the blood vessels in shock consists of two principal components: vascular smooth muscle dysfunction, and endothelial dysfunction. The vascular smooth muscle dysfunction (a progressive, therapy-resistant loss of responsiveness of the vascular smooth muscle to vasoconstrictor catecholamines, such as noradrenaline) leads to a progressive deterioration of blood pressure in patients with circulatory shock. The endothelial dysfunction (loss of the ability of the vascular endothelium to produce nitric oxide and other local endothelium-derived factors) contributes to the impairment of microvascular blood fl ow, to the enhanced adhesion and activation of neutrophils and platelets, to coagulation problems, and perfusion/metabolism mismatch in the affected organs. Here we overview the role of nitric oxide (NO) in the pathogenesis of vascular contractile dysfunction in circulatory shock. We describe the results of published studies involving shock models induced by bacterial lipopolysaccharide (LPS), and by cecal ligation and puncture (CLP), a polymicrobial model of sepsis. Among the many contributing factors, we focus on the role of cyclic GMP (cGMP) dependent pathways as well as a number of cGMP independent pathways. We will also outline the role of oxidative/nitrosative stress, peroxynitrite and poly(ADP-ribose) polymerase (PARP) and vascular potassium channels in the sepsis-associated alterations in vascular smooth muscle contractility. |
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