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題 名 | High-dose Quetiapine for the Treatment of Schizophrenia with Inadequate Response to Quetiapine 600 mg/day=以高劑量Quetiapine治療對Quetiapine劑量600毫克治療反應不佳的精神分裂症患者 |
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作 者 | 吳坤鴻; 詹宏裕; 吳俊毅; 陳快樂; 孫效儒; | 書刊名 | Taiwanese Journal of Psychiatry |
卷 期 | 24:4 2010.12[民99.12] |
頁 次 | 頁307-312+328 |
分類號 | 418.21 |
關鍵詞 | 精神分裂症; 療效不佳; 高劑量; Schizophrenia; Inadequate response; Quetiapine; High dose; |
語 文 | 英文(English) |
英文摘要 | Objectives: In this study, we aimed to determine the efficacy of high-dose quetiapine (≧800 mg/day) for Taiwanese patients with schizophrenia and with inadequate response to quetiapine 600 mg/day of more than 4 weeks. Methods: The study was a six-week, open-label study. We assessed patients' treatment response and side effects with clinical global impression-severity (CGI-S), brief psychiatric rating scale (BPRS), and extrapyramidal syndrome rating scale (ESRS). Results: Six patients participated in this study. After this six-week study, the mean dose of quetiapine was 1000 mg/day. The mean scores of BPRS and CGI-S were improved from 44.2±5.5 to 35.5±18.1 (p=0.344) and 4.7±0.8 to 3.7±1.8 (p=0.084), respectively. Four patients met the criteria of treatment responder and no patients suffered from severe adverse events. Conclusion: Although no significant statistical differences in this study were observed due to small sample size, the improvements of mean total scores of BPRS and CGI-S were 19.7% and 21.3%, respectively, and 66.7% of the patients met treatment responder criteria. For Taiwanese patients with schizophrenia and with inadequate treatment response to quetiapine 600 mg/day, we suggest that high-dose quetiapine can be effective and tolerable. |
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